DNA Methyltransferases 1 and 3b Expression in Huh-7 Cells Expressing HCV Core Protein of Different Genotypes

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• 作者：Giorgia Benegiamo (1)
  Manlio Vinciguerra (2)
  Gianluigi Mazzoccoli (3)
  Ada Piepoli (1)
  Angelo Andriulli (1)
  Valerio Pazienza (1) pazienza_valerio@yahoo.it
• 关键词：HCV core &#8211 ; DNMTs &#8211 ; CDH1 &#8211 ; STAT3 &#8211 ; SIRT1
• 刊名：Digestive Diseases and Sciences
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：57
• 期：6
• 页码：1598-1603
• 全文大小：383.0 KB
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• 作者单位：1. Gastroenterology Unit, I.R.C.C.S 鈥淐asa Sollievo della Sofferenza鈥?Hospital, viale dei Cappuccini n.1, 71013 San Giovanni Rotondo, Foggia, Italy2. Institute of Hepatology, Foundation for Liver Research, London, UK3. Department of Internal Medicine, 鈥淐asa Sollievo della Sofferenza鈥?Hospital, San Giovanni Rotondo, Foggia, Italy
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gastroenterology
  Hepatology
  Oncology
  Transplant Surgery
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-2568

文摘

Background Hepatitis C virus infects ~3 % of the population and it is a risk factor for hepatocarcinogenesis. The epigenetic mechanisms of HCV-induced hepatocyte transformation towards malignancy in this context are unclear.