KH-type splicing regulatory protein (KHSRP) contributes to tumorigenesis by promoting miR-26a maturation in small cell lung cancer

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• 作者：Lihua Tong ; Yingshan Luo ; Ting Wei ; Linlang Guo…
• 关键词：KH ; type splicing regulatory protein (KHSRP) ; Small cell lung cancer (SCLC) ; Tumorigenesis ; mir ; 26a ; Phosphatase and tensin homolog deleted on chromosome ten (PTEN)
• 刊名：Molecular and Cellular Biochemistry
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：422
• 期：1-2
• 页码：61-74
• 全文大小：8,255 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Medical Biochemistry
  Oncology
  Cardiology
  
• 出版者：Springer Netherlands
• ISSN：1573-4919
• 卷排序：422

文摘

KH-type splicing regulatory protein (KHSRP) is a multifunctional RNA-binding protein that has a role in tumorigenesis of small cell lung cancer. The KHSRP protein level was shown to be significantly increased in small cell lung cancer (SCLC) tumor tissues compared with normal lung tissues by immunohistochemical staining. Moreover, KHSRP protein levels were strongly associated with T stage in patients with SCLC. Using in vitro assays, we found that knockdown of the KHSRP gene inhibited cell proliferation and increased cell apoptosis but had no effect on cell migration and invasion. We also showed that down-regulation of the KHSRP gene suppressed tumor growth in vivo. Further analyses indicated that KHSRP was involved in miR-26a maturation and inhibited the expression of PTEN in SCLC cells. Taken together, these findings suggested that KHSRP plays an important role in SCLC tumorigenesis and could be a potential novel therapeutic target for SCLC treatment.