Combined measurement of soluble and cellular ICAM-1 among children with Plasmodium falciparum malaria in Uganda
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- 作者：Christine M Cserti-Gazdewich (1)
Walter H Dzik (2)
Laura Erdman (3)
Isaac Ssewanyana (4)
Aggrey Dhabangi (5)
Charles Musoke (5)
Kevin C Kain (3) - 刊名：Malaria Journal
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：9
- 期：1
- 全文大小：1403KB
- 参考文献：1. Lawson C, Wolf S: ICAM-1 signaling in endothelial cells. / Pharmacol Rep 2009, 61:22鈥?2.
2. Baratin M, Roetynck S, Pouvelle B, Lemmers C, Viebig NK, Johansson S, Bierling P, Scherf A, Gysin J, Vivier E, Ugolini S: Dissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum -infected erythrocytes by natural killer cells. / PLoS ONE 2007, 2:e228. CrossRef
3. Walther M, Woodruff J, Edele F, Jeffries D, Tongren JE, King E, Andrews L, Bejon P, Gilbert SC, De Souza JB, Sinden R, Hill AV, Riley EM: Innate immune responses to human malaria: heterogeneous cytokine responses to blood-stage Plasmodium falciparum correlate with parasitological and clinical outcomes. / J Immunol 2006, 177:5736鈥?745.
4. Othoro C, Moore JM, Wannemuehler KA, Moses S, Lal A, Otieno J, Nahlen B, Slutsker L, Shi YP: Elevated gamma interferon-producing NK cells, CD45RO memory-like T cells, and CD4 T cells are associated with protection against malaria infection in pregnancy. / Infect Immun 2008, 76:1678鈥?685. CrossRef
5. Su Z, Stevenson MM: Central role of endogenous gamma interferon in protective immunity against blood-stage Plasmodium chabaudi AS infection. / Infect Immun 2000, 68:4399鈥?406. CrossRef
6. Porta J, Carota A, Pizzolato GP, Wildi E, Widmer MC, Margairaz C, Grau GE: Immunopathological changes in human cerebral malaria. / Clin Neuropathol 1993, 12:142鈥?46.
7. Grau GE, Mackenzie CD, Carr RA, Redard M, Pizzolato G, Allasia C, Cataldo C, Taylor TE, Molyneux ME: Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria. / J Infect Dis 2003, 187:461鈥?66. CrossRef
8. Patnaik JK, Das BS, Mishra SK, Mohanty S, Satpathy SK, Mohanty D: Vascular clogging, mononuclear cell margination, and enhanced vascular permeability in the pathogenesis of human cerebral malaria. / Am J Trop Med Hyg 1994, 51:642鈥?47.
9. Chakravorty SJ, Craig A: The role of ICAM-1 in Plasmodium falciparum cytoadherence. / Eur J Cell Biol 2005, 84:15鈥?7. CrossRef
10. Silamut K, Phu NH, Whitty C, Turner GD, Louwrier K, Mai NT, Simpson JA, Hien TT, White NJ: A quantitative analysis of the microvascular sequestration of malaria parasites in the human brain. / Am J Pathol 1999, 155:395鈥?10. CrossRef
11. Turner GD, Morrison H, Jones M, Davis TM, Looareesuwan S, Buley ID, Gatter KC, Newbold CI, Pukritayakamee S, Nagachinta B: An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration. / Am J Pathol 1994, 145:1057鈥?069.
12. Armah H, Dodoo AK, Wiredu EK, Stiles JK, Adjei AA, Gyasi RK, Tettey Y: High-level cerebellar expression of cytokines and adhesion molecules in fatal, paediatric, cerebral malaria. / Ann Trop Med Parasitol 2005, 99:629鈥?47. CrossRef
13. Turner GD, Ly VC, Nguyen TH, Tran TH, Nguyen HP, Bethell D, Wyllie S, Louwrier K, Fox SB, Gatter KC, Day NP, Tran TH, White NJ, Berendt AR: Systemic endothelial activation occurs in both mild and severe malaria. Correlating dermal microvascular endothelial cell phenotype and soluble cell adhesion molecules with disease severity. / Am J Pathol 1998, 152:1477鈥?487.
14. Newbold C, Warn P, Black G, Berendt A, Craig A, Snow B, Msobo M, Peshu N, Marsh K: Receptor-specific adhesion and clinical disease in Plasmodium falciparum . / Am J Trop Med Hyg 1997, 57:389鈥?98.
15. Tripathi AK, Sullivan DJ, Stins MF: Plasmodium falciparum -infected erythrocytes increase intercellular adhesion molecule 1 expression on brain endothelium through NF-kappaB. / Infect Immun 2006, 74:3262鈥?270. CrossRef
16. Favre N, Da Laperousaz C, Ryffel B, Weiss NA, Imhof BA, Rudin W, Lucas R, Piguet PF: Role of ICAM-1 (CD54) in the development of murine cerebral malaria. / Microbes Infect 1999, 1:961鈥?68. CrossRef
17. Graninger W, Prada J, Neifer S, Zotter G, Thalhammer F, Kremsner PG: Upregulation of ICAM-I by Plasmodium falciparum : in vitro and in vivo studies. / J Clin Pathol 1994, 47:653鈥?56. CrossRef
18. Hviid L, Theander TG, Elhassan IM, Jensen JB: Increased plasma levels of soluble ICAM-1 and ELAM-1 (E-selectin) during acute Plasmodium falciparum malaria. / Immunol Lett 1993, 36:51鈥?8. CrossRef
19. Jakobsen PH, Morris-Jones S, Ronn A, Hviid L, Theander TG, Elhassan IM, Bygbjerg IC, Greenwood BM: Increased plasma concentrations of sICAM-1, sVCAM-1 and sELAM-1 in patients with Plasmodium falciparum or P. vivax malaria and association with disease severity. / Immunology 1994, 83:665鈥?69.
20. Peyron F, Caux-Menetrier C, Roux-Lombard P, Niyongabo T, Aubry P, Deloron P: Soluble intercellular adhesion molecule-1 and E-selectin levels in plasma of falciparum malaria patients and their lack of correlation with levels of tumor necrosis factor alpha, interleukin 1 alpha (IL-1 alpha), and IL-10. / Clin Diagn Lab Immunol 1994, 1:741鈥?43.
21. Vogetseder A, Ospelt C, Reindl M, Schober M, Schmutzhard E: Time course of coagulation parameters, cytokines and adhesion molecules in Plasmodium falciparum malaria. / Trop Med Int Health 2004, 9:767鈥?73. CrossRef
22. McGuire W, Hill AV, Greenwood BM, Kwiatkowski D: Circulating ICAM-1 levels in falciparum malaria are high but unrelated to disease severity. / Trans R Soc Trop Med Hyg 1996, 90:274鈥?76. CrossRef
23. Tchinda VH, Tadem AD, Tako EA, Tene G, Fogako J, Nyonglema P, Sama G, Zhou A, Leke RG: Severe malaria in Cameroonian children: correlation between plasma levels of three soluble inducible adhesion molecules and TNF-alpha. / Acta Trop 2007, 102:20鈥?8. CrossRef
24. Jenkins NE, Chakravorty SJ, Urban BC, Kai OK, Marsh K, Craig AG: The effect of Plasmodium falciparum infection on expression of monocyte surface molecules. / Trans R Soc Trop Med Hyg 2006, 100:1007鈥?012. CrossRef
25. / Republic of Uganda: National Malaria Treatment Policy Kampala: Ministry of Health; 2006.
26. Dzik WH, Cserti-Gazdewich CM, Ssewanyana I, Delelys M, Preffer FI: When monocytes and platelets compete: The effect of platelet count on the flow cytometric measurement of monocyte CD36. / Cytometry B Clin Cytom 2010, 78:81鈥?7.
27. ZunZun.com Online Curve Fitting and Surface Fitting Web Site [http://www.zunzun.com]
28. Champagne B, Tremblay P, Cantin A, St Pierre Y: Proteolytic cleavage of ICAM-1 by human neutrophil elastase. / J Immunol 1998, 161:6398鈥?405.
29. Fernandez-Reyes D, Craig AG, Kyes SA, Peshu N, Snow RW, Berendt AR, Marsh K, Newbold CI: A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya. / Hum Mol Genet 1997, 6:1357鈥?360. CrossRef
30. Fry AE, Auburn S, Diakite M, Green A, Richardson A, Wilson J, Jallow M, Sisay-Joof F, Pinder M, Griffiths MJ, Peshu N, Williams TN, Marsh K, Molyneux ME, Taylor TE, Rockett KA, Kwiatkowski DP: Variation in the ICAM1 gene is not associated with severe malaria phenotypes. / Genes Immun 2008, 9:462鈥?69. CrossRef
31. Jenkins NE, Mwangi TW, Kortok M, Marsh K, Craig AG, Williams TN: A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children. / Clin Infect Dis 2005, 41:1817鈥?819. CrossRef
32. Otto VI, Damoc E, Cueni LN, Schurpf T, Frei R, Ali S, Callewaert N, Moise A, Leary JA, Folkers G, Przybylski M: N-glycan structures and N-glycosylation sites of mouse soluble intercellular adhesion molecule-1 revealed by MALDI-TOF and FTICR mass spectrometry. / Glycobiology 2006, 16:1033鈥?044. CrossRef
33. Zhang H, Liu AY, Loriaux P, Wollscheid B, Zhou Y, Watts JD, Aebersold R: Mass spectrometric detection of tissue proteins in plasma. / Mol Cell Proteomics 2007, 6:64鈥?1. - 作者单位：Christine M Cserti-Gazdewich (1)
Walter H Dzik (2)
Laura Erdman (3)
Isaac Ssewanyana (4)
Aggrey Dhabangi (5)
Charles Musoke (5)
Kevin C Kain (3)
1. Department of Laboratory Medicine & Pathobiology, University Health Network/University of Toronto, Toronto, Canada
2. Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
3. McLaughlin-Rotman Centre for Global Health, University Health Network/University of Toronto, Toronto, Canada
4. Joint Clinical Research Centre, Kampala, Uganda
5. Makerere University, Kampala Uganda
文摘
Background Intercellular adhesion molecule-1 (ICAM-1) is a cytoadhesion molecule implicated in the pathogenesis of Plasmodium falciparum malaria. Elevated levels of soluble ICAM-1 (sICAM-1) have previously been reported with increased malaria disease severity. However, studies have not yet examined both sICAM-1 concentrations and monocyte ICAM-1 expression in the same cohort of patients. To better understand the relationship of soluble and cellular ICAM-1 measurements in malaria, both monocyte ICAM-1 expression and sICAM-1 concentration were measured in children with P. falciparum infection exhibiting a spectrum of clinical severity. Methods Samples were analysed from 160 children, aged 0.5 to 10.8 years, with documented P. falciparum malaria in Kampala, Uganda. The patients belonged to one of three pre-study defined groups: uncomplicated malaria (UM), severe non-fatal malaria (SM-s), and fatal malaria (SM-f). Subset analysis was done on those with cerebral malaria (CM) or severe malaria anaemia (SMA). Monocyte ICAM-1 was measured by flow cytometry. sICAM-1 was measured by enzyme immunoassay. Results Both sICAM-1 and monocyte cell-surface ICAM-1 followed a log-normal distribution. Median sICAM-1 concentrations increased with greater severity-of-illness: 279 ng/mL (UM), 462 ng/mL (SM-s), and 586 ng/mL (SM-f), p < 0.0001. sICAM-1 levels were not statistically different among children with CM compared to SMA. Monocyte ICAM-1 expression was significantly higher in cases of UM compared with SM-s or SM-f (p < 0.001) and was higher among the subset of patients with CM compared with SMA, p < 0.0014. The combination of sICAM-1 and cellular ICAM-1 identified distinct categories of patients (UM with low sICAM-1 and higher monocyte ICAM-1, CM with both sICAM-1 and monocyte ICAM-1 high, and SMA with sICAM-1 high but monocyte ICAM-1 low). Conclusion In this cohort of children with P. falciparum malaria, sICAM-1 levels were associated with severity-of-illness. Patients with UM had higher monocyte ICAM-1 expression consistent with a role for monocyte ICAM-1 in immune clearance during non-severe malaria. Among the subsets of patients with either SMA or CM, monocyte ICAM-1 levels were higher in CM, consistent with the role of ICAM-1 as a marker of cytoadhesion. Categories of disease in pediatric malaria may exhibit specific combinations of soluble and cellular ICAM-1 expression.