Cryptotanshinone enhances the effect of Arsenic trioxide in treating liver cancer cell by inducing apoptosis through downregulating phosphorylated- STAT3 in vitro and in vivo
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- 作者：Li Shen ; Guangshun Zhang ; Zhaohuan Lou…
- 关键词：Arsenic trioxide ; Cryptotanshinone ; Cell apoptosis ; Liver cancer
- 刊名：BMC Complementary and Alternative Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：3128KB
- 刊物主题：Complementary & Alternative Medicine; Internal Medicine; Chiropractic Medicine;
- 出版者：BioMed Central
- ISSN：1472-6882
- 卷排序：17
文摘
BackgroundArsenic trioxide (ATO) is approved for treating terminal-stage liver cancer in China. Cryptotanshinone (CT), a STAT3 inhibitor, has exhibited certain anti-tumor potency; however, the use of CT enhanced ATO for treating liver cancer has not been reported. Here we try to elucidate how CT could enhance the efficacy of ATO for treating liver cancer and its correlation to STAT3 in vitro and in vivo.