The atypical antipsychotics olanzapine and quetiapine, but not haloperidol, reduce ACTH and cortisol secretion in healthy subjects

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• 作者：Stefan Cohrs ; Cornelia R?her ; Wolfgang Jordan ; Andreas Meier ; Gerald Huether ; Wolfgang Wuttke ; Eckart Rüther and Andrea Rodenbeck
• 刊名：Psychopharmacology
• 出版年：2006
• 出版时间：March 2006
• 年：2006
• 卷：185
• 期：1
• 页码：11-18
• 全文大小：148 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale Increased activity of the hypothalamic–pituitary–adrenal (HPA) axis is an important aspect of the pathophysiology of major depression and schizophrenia. Despite the usefulness of atypical antipsychotics in the treatment of depression and their positive influence on cognitive functioning possibly related to their impact on cortisol, little is known about their effect on HPA axis function.