Intracameral concentrations of the fibrinolytic system components in patients with age-related macular degeneration

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• 作者：Thomas Bertelmann (1)
  Marta Spychalska (1)
  Laura Kohlberger (1)
  Stefan Strodthoff (1)
  Michael Witteborn (1)
  Nadia Kicova (1)
  Ulrich Sachs (2)
  Sebastian Irle (3)
  Stefan Mennel (4)
  
• 关键词：Intraocular fibrinolytic system ; Age ; related macular degeneration ; AMD ; Vitreomacular traction ; VMT ; Vitreomacular adhesion ; VMA ; Enzymatic vitreolysis ; Plasminogen ; Tissue plasminogen activator ; t ; PA
• 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：251
• 期：12
• 页码：2697-2704
• 全文大小：
• 作者单位：Thomas Bertelmann (1)
  Marta Spychalska (1)
  Laura Kohlberger (1)
  Stefan Strodthoff (1)
  Michael Witteborn (1)
  Nadia Kicova (1)
  Ulrich Sachs (2)
  Sebastian Irle (3)
  Stefan Mennel (4)
  
  1. Department of Ophthalmology, Philipps-University Marburg, Baldingerstrae, 35043, Marburg, Germany
  2. Department of Transfusion Medicine and Haemostaseology, Philipps-University Marburg, Marburg, Germany
  3. Institute of Medical Biometry and Epidemiology, Philipps-University Marburg, Marburg, Germany
  4. Department of Ophthalmology, Feldkirch Regional Hospital, Feldkirch, Austria
  
• ISSN：1435-702X

文摘

Purpose To detect the intracameral concentrations and activities of plasminogen and other components of the fibrinolytic system, and to investigate whether those concentrations and activities are higher in patients with age-related macular degeneration (AMD) in comparison to healthy controls. Methods Prospective case series of 93 patients scheduled for standard phacoemulsification. Results Mean plasminogen activity in patients with non-exsudative AMD (n=24) revealed to be 0.06%N, in patients with exudative AMD (n=7) 0.03%N and in healthy controls (n=43) 0.02%N (p=0.38, ANOVA). Plasminogen activator inhibitor I (PAI-1) was detected in neither group. Alpha2ntiplasmin activity was 1.61U/ml in the non-exudative AMD group (n=27), 0U/ml in the exudative AMD group (n=7) and 0.54U/ml in the control group (n=48) (p=0.1, ANOVA). Concentrations of plasmin2ntiplasmin complex (PAP) were detected at levels of 17.91ng/ml in the non-exudative AMD group (n=11), of 16.6ng/ml in the exudative AMD group (n=5), and of 17.43ng/ml in the control group (n=14) (p=0.92, ANOVA). Conclusions Plasminogen is present with a very low activity in aqueous humor. There are no significant differences in aqueous humor concentrations or activities of plasminogen and other components of the fibrinolytic system between patients with non-exudative AMD, exudative AMD, and healthy controls. Further studies should investigate vitreous samples instead of aqueous humor samples. A careful and accurate workup of obtained intraocular fluids is needed to detect the low concentrations and activities of the parameters analyzed.