Effect of photodynamic therapy on the function of the outer blood-retinal barrier in an in vitro model

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• 作者：Stefan Mennel ; Silvia Peter ; Carsten H. Meyer and Gabriele Thumann
• 关键词：Photodynamic therapy ; PDT ; Blood retinal barrier ; BRB ; Verteporfin ; Retinal pigment epithelium ; RPE
• 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
• 出版年：2006
• 出版时间：August, 2006
• 年：2006
• 卷：244
• 期：8
• 页码：1015-1021
• 全文大小：245 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Ophthalmology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-702X

文摘

Background Photodynamic therapy (PDT) is a well established clinical treatment for age-related macular degeneration (AMD), and comprises intravenous injection of verteporfin and subsequent application of a non-thermal laser beam to the area of AMD to induce selective vascular occlusion. Since there is evidence that PDT may cause outer blood-retinal barrier (BRB) breakdown and possibly RPE cell alteration, we investigated the effect of PDT on the BRB function of the RPE in an in vitro model.