Determination of widely used non-steroidal anti-inflammatory drugs in biological fluids using simultaneous derivatization and air-assisted liquid–liquid microextraction followed by gas chromatography–flame ionization detection

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• 作者：Mir Ali Farajzadeh ; Hassan Nasrollahpour…
• 关键词：Air ; assisted liquid–liquid microextraction ; Non ; steroidal anti ; inflammatory drugs ; Gas chromatography ; Derivatization ; Biological fluids
• 刊名：Journal of the Iranian Chemical Society
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：13
• 期：2
• 页码：289-298
• 全文大小：1,308 KB
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• 作者单位：Mir Ali Farajzadeh (1)
  Hassan Nasrollahpour (1)
  Mohammad Reza Afshar Mogaddam (1)
  Leila Khoshmaram (2)
  
  1. Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
  2. Department of Chemistry, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran
  
• 刊物主题：Analytical Chemistry; Inorganic Chemistry; Physical Chemistry; Biochemistry, general; Organic Chemistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1735-2428

文摘

A sensitive and reliable method for the extraction, preconcentration, and determination of non-steroidal acidic anti-inflammatory drugs (ibuprofen, naproxen, and diclofenac) from biological samples has been developed using simultaneous derivatization and air-assisted liquid–liquid microextraction followed by gas chromatography–flame ionization detection. In this method, a mixture of an extraction solvent (chloroform) and a derivatizing agent (butyl chloroformate) is added into a glass test tube containing an aqueous sample of the analytes and picoline (catalyst). The mixture is dispersed by repeatedly aspirating and dispensing via a syringe. By this action, derivatization and extraction of the selected analytes is performed simultaneously. Under the optimal conditions, enrichment factors and extraction recoveries were obtained in the ranges 364–412 and 72–82 %, respectively. The linear ranges were broad with correlation coefficients higher than 0.995. Limits of detection were obtained in the ranges 0.06–3.30 and 0.24–13 ng mL−1 in urine and plasma samples, respectively. Limits of quantification were 0.21–9.2 ng mL−1 in urine and 0.84–37 ng mL−1 for plasma sample. Relative standard deviations were lower than 5.2 % for six repeated determinations at a concentration of 25 ng mL−1 of each analyte. Finally, the developed method was successfully applied to determine the selected analytes in urine and plasma samples. Keywords Air-assisted liquid–liquid microextraction Non-steroidal anti-inflammatory drugs Gas chromatography Derivatization Biological fluids