Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F2 mice
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- 作者：Godfred L. Masinde ; Xinmin Li ; Weikuan Gu ; Heather Davidson ; Melanie Hamilton-Ulland ; Jon Wergedal ; Subburaman Mohan and David Baylink
- 关键词：Lean body mass Quantitative trait loci Epistatic interactions
- 刊名：Functional & Integrative Genomics
- 出版年：2002
- 出版时间：August 2002
- 年：2002
- 卷：2
- 期：3
- 页码：98-104
- 全文大小：180 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Cell Biology
Plant Genetics and Genomics
Microbial Genetics and Genomics
Biochemistry
Bioinformatics
Animal Genetics and Genomics - 出版者：Springer Berlin / Heidelberg
- ISSN：1438-7948
文摘
Studies on the genetic mechanisms involved in the regulation of lean body mass (LBM) in mammals are minimal, although LBM is associated with a competent immune system and an overall good (healthy) body functional status. In this study, we performed a high-density genome-wide scan using 633 (MRL/MPJ × SJL/J) F2 intercross to identify the quantitative trait loci (QTL) involved in the regulation of LBM. We hypothesized that additional QTL can be identified using a different mouse cross (MRL/SJL cross). Ten QTL were identified for LBM on chromosomes (chrs) 2, 6, 7, 9,13 and 14. Of those ten, QTL on chrs 6, 7 and 14 were exclusive to LBM, while QTL on chrs 4 and 11 were exclusively body length. LBM QTL on chrs 2 and 9 overlap with those of size. Altogether, the ten LBM QTL explained 41.2% of phenotypic variance in F2 mice. Five significantly interacting loci that may be involved in the regulation of LBM were identified and accounted for 24.4% of phenotypic variance explained by the QTL. Five epistatic interactions, contributing 22.9% of phenotypic variance, were identified for body length. Interacting loci on chr 2 may influence LBM by regulating body length. Therefore, epistatic interactions as well as single QTL effects play an important role in the regulation of LBM.