[6]-Gingerol-loaded cellulose acetate electrospun fibers as a topical carrier for controlled release
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- 作者：Thanaporn Chantarodsakun (1)
Thammasit Vongsetskul (1)
Kulachart Jangpatarapongsa (2)
Patoomratana Tuchinda (1)
Sukanda Uamsiri (1)
Chuthamas Bamrungcharoen (1)
Supeecha Kumkate (3)
Pakorn Opaprakasit (4)
Pramuan Tangboriboonrat (1) - 关键词：Cellulose acetate ; Controlled release ; Electrospinning ; [6] ; Gingerol ; Ultrafine fiber
- 刊名：Polymer Bulletin
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：71
- 期：12
- 页码：3163-3176
- 全文大小：799 KB
- 参考文献：1. Vongsetskul T, Kongjumnean P, Sunintaboon P, Rangkupan R, Tangboriboonrat P (2012) Electrospun composite fibers of polyvinylpyrrolidone with embedded poly(methyl methacrylate)–polyethyleneimine core–shell particles. Polym Bull 69:1115-123. doi:
2. Reneker DH, Chun I (1996) Nanometre diameter fibres of polymer, produced by electrospinning. Nanotechnology 7:216-23. doi:
3. Suwantong O, Ruktanonchai U, Supaphol P (2008) Electrospun cellulose acetate fiber mats containing asiaticoside or / Centella Asiatica crude extract and the release characteristics of asiaticoside. Polymer 49:4239-247. doi:
4. Suwantong O, Opanasopit P, Ruktanonchai U, Supaphol P (2007) Electrospun cellulose acetate fiber mats containing curcumin and release characteristic of the herbal substance. Polymer 48:7546-557. doi:
5. Han J, Chen TX, Branford-White CJ, Zhu LM (2009) Electrospun shikonin-loaded PCL/PTMC composite fiber mats with potential biomedical applications. Int J Pharm 383:215-21. doi:
6. Sun X, Williams GR, Hou X, Zhu L (2013) Electrospun curcumin-loaded fibers with potential biomedical applications. Carbohyd Polym 94:147-53. doi:
7. Fischer S, Thummler K, Volkert B, Hettrich K, Schmidt I, Fischer K (2008) Properties and applications of cellulose acetate. Macromol Symp 262:89-6. doi:
8. Aoki D, Teramoto Y, Nishio Y (2007) SH-containing cellulose acetate derivatives: preparation and characterization as a shape memory-recovery material. Biomacromolecules 8:3749-757. doi:
9. Puls J, Wilson SA, Puls DH (2011) Degradation of cellulose acetate-based materials: a review. J Polym Environ 19:152-65. doi:
10. Haghighi A, Tavalaei N, Owlia MB (2006) Effects of ginger on primary knee osteoarthritis. Indian J Rheumatol 1:3-. doi:
11. Ali BH, Blunden G, Tanira MO, Nemmar A (2008) Some phytochemical, pharmacological and toxicological properties of ginger ( / Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol 46:409-20. doi:
12. Minghetti P, Sosaz S, Cilurzo F, Casiraghi A, Alberti E, Tubaro A, Della Loggia R, Montanari L (2007) Evaluation of the topical anti-inflammatory activity of ginger dry extracts from solutions and plasters. Planta Med 73:1525-530. doi:
13. Afzal M, Al-Hadidi D, Menon M, Pesek J, Dhami MS (2001) Ginger: an ethnomedical, chemical and pharmacological review. Drug Metab Drug Interact 18:159-90. doi:
14. Grzanna R, Lindmark L, Fro - 作者单位：Thanaporn Chantarodsakun (1)
Thammasit Vongsetskul (1)
Kulachart Jangpatarapongsa (2)
Patoomratana Tuchinda (1)
Sukanda Uamsiri (1)
Chuthamas Bamrungcharoen (1)
Supeecha Kumkate (3)
Pakorn Opaprakasit (4)
Pramuan Tangboriboonrat (1)
1. Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand
2. Center for Innovation Development and Technology Transfer, Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhonprathom, 73170, Thailand
3. Department of Biology, Faculty of Science, Mahidol University, Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand
4. School of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT), Thammasat University, Pathum Thani, 12120, Thailand - ISSN：1436-2449
文摘
[6]-Gingerol (6?% w/v)-loaded cellulose acetate (12?% w/v CA; MW?~?3?×?104 g/mol) fibers (375?±?107?nm) were prepared by electrospinning at 7.5?kV. ATR-FTIR spectra indicated that the mixture was miscible at this composition. Differential scanning calorimetry revealed that [6]-gingerol was uniformly dispersed in the CA matrix and interrupted the hydrogen bond formation among the CA chains. Controlled release study showed that ~97?% of the loaded [6]-gingerol could be released from the loaded fibers to the acetate buffer solution at 37?°C, whereas only ~74?% of it could be done from the corresponding films. About 92?% of [6]-gingerol in the fibers was dramatically released within 4?h. Release was mainly governed by a diffusion-controlled mechanism. The radical scavenging assay showed antioxidant activity of the loaded fibers. The in vitro cytotoxicity test revealed that the viability of L-929 mouse fibroblast cells to the loaded fibers was ~65?%.