Possible extracardiac predictors of aortic dissection in Marfan syndrome
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- 作者：Bence ágg ; Kálmán Benke ; Bálint Szilveszter ; Miklós Pólos…
- 关键词：Marfan syndrome ; Aortic dissection ; Predictors ; Cardiac surgery
- 刊名：BMC Cardiovascular Disorders
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：14
- 期：1
- 全文大小：480 KB
- 参考文献：1. Gao, LG, Luo, F, Hui, RT, Zhou, XL (2010) Recent molecular biological progress in Marfan syndrome and Marfan-associated disorders. Ageing Res Rev 9: pp. 363-368 CrossRef
2. Colovati, ME, da Silva, LR, Takeno, SS, Mancini, TI, N Dutra, AR, Guilherme, RS, de Mello, CB, Melaragno, MI, A Perez, AB (2012) Marfan syndrome with a complex chromosomal rearrangement including deletion of the FBN1 gene. Mol Cytogenet 5: pp. 5 CrossRef
3. Holm, TM, Habashi, JP, Doyle, JJ, Bedja, D, Chen, Y, van Erp, C, Lindsay, ME, Kim, D, Schoenhoff, F, Cohn, RD, Loeys, BL, Thomas, CJ, Patnaik, S, Marugan, JJ, Judge, DP, Dietz, HC (2011) Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice. Science 332: pp. 358-361 CrossRef
4. Chung, AW, Yang, HH, Radomski, MW, van Breemen, C (2008) Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in marfan syndrome through the inhibition of matrix metalloproteinase-2 and ?. Circ Res 102: pp. e73-e85 CrossRef
5. Ahimastos, AA, Aggarwal, A, Savarirayan, R, Dart, AM, Kingwell, BA (2010) A role for plasma transforming growth factor-beta and matrix metalloproteinases in aortic aneurysm surveillance in Marfan syndrome?. Atherosclerosis 209: pp. 211-214 CrossRef
6. Benke, K, ágg, B, Szilveszter, B, Tarr, F, Nagy, ZB, Pólos, M, Daróczi, L, Merkely, B, Szabolcs, Z (2013) The role of TGF-β in Marfan syndrome. Cardiol J 20: pp. 227-234 CrossRef
7. Neri, E, Barabesi, L, Buklas, D, Vricella, LA, Benvenuti, A, Tucci, E, Sassi, C, Masseti, M (2005) Limited role of aortic size in the genesis of acute type A aortic dissection. Eur J Cardiothorac Surg 28: pp. 857-863 CrossRef
8. Détaint, D, Faivre, L, Collod-Beroud, G, Child, AH, Loeys, BL, Binquet, C, Gautier, E, Arbustini, E, Mayer, K, Arslan-Kirchner, M, Stheneur, C, Halliday, D, Beroud, C, Bonithon-Kopp, C, Claustres, M, Plauchu, H, Robinson, PN, Kiotsekoglou, A, De Backer, J, Adés, L, Francke, U, De Paepe, A, Boileau, C, Jondeau, G (2010) Cardiovascular manifestations in men and women carrying a FBN1 mutation. Eur Heart J 31: pp. 2223-2229 CrossRef
9. Song, HK, Kindem, M, Bavaria, JE, Dietz, HC, Milewicz, DM, Devereux, RB, Eagle, KA, Maslen, CL, Kroner, BL, Pyeritz, RE, Holmes, KW, Weinsaft, JW, Menasche, W, Rayekes, W, Lemaire, SA (2012) Long-term implications of emergency versus elective proximal aortic surgery in patients with Marfan syndrome in the genetically triggered thoracic aortic aneurysms and cardiovascular conditions consortium registry. J Thorac Cardiovasc Surg 143: pp. 282-286 CrossRef
10. Zehr, KJ, Orszulak, TA, Mullany, CJ, Matloobi, A, Daly, RC, Dearani, JA, Sundt, TM, Puga, FJ, Danielson, GK, Schaff, HV (2004) Surgery for aneurysms of the aortic root: a 30-year experience. Circ 110: pp. 1364-1371 CrossRef
11. Geisbuesch, S, Schray, D, Bischoff, MS, Lin, HM, Di Luozzo, G, Griepp, RB (2012) Frequency of reoperations in patients with Marfan syndrome. Ann Thorac Surg 93: pp. 1496-1501 CrossRef
12. Radu, NC, Kirsch, EW, Hillion, ML, Lagneau, F, Drouet, L, Loisance, D (2007) Embolic and bleeding events after modified Bentall procedure in selected patients. Heart 93: pp. 107-112 CrossRef
13. Meijboom, LJ, Timmermans, J, Zwinderman, AH, Engelfriet, PM, Mulder, BJ (2005) Aortic root growth in men and women with the Marfan’s syndrome. Am J Cardiol 96: pp. 1441-1444- 刊物主题：Cardiology; Cardiac Surgery; Angiology; Blood Transfusion Medicine; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2261
文摘
Background According to previous studies, aortic diameter alone seems to be insufficient to predict the event of aortic dissection in Marfan syndrome (MFS). Determining the optimal schedule for preventive aortic root replacement (ARR) aortic growth rate is of importance, as well as family history, however, none of them appear to be decisive. Thus, the aim of this study was to search for potential predictors of aortic dissection in MFS. Methods A Marfan Biobank consisting of 79 MFS patients was established. Thirty-nine MFS patients who underwent ARR were assigned into three groups based on the indication for surgery (dissection, annuloaortic ectasia and prophylactic surgery). The prophylactic surgery group was excluded from the study. Transforming growth factor-β (TGF-β) serum levels were measured by ELISA, relative expression of c-Fos, matrix metalloproteinase 3 and 9 (MMP-3 and ?) were assessed by RT-PCR. Clinical parameters, including anthropometric variables - based on the original Ghent criteria were also analyzed. Results Among patients with aortic dissection, TGF-β serum level was elevated (43.78?±-.51 vs. 31.64?±-.99?ng/l, p--.0001), MMP-3 was up-regulated (Ln2α--.87, p--.062) and striae atrophicae were more common (92% vs. 41% p--.027) compared to the annuloaortic ectasia group. Conclusions We found three easily measurable parameters (striae atrophicae, TGF-β serum level, MMP-3) that may help to predict the risk of aortic dissection in MFS. Based on these findings a new classification of MFS, that is benign or malignant is also proposed, which could be taken into consideration in determining the timing of prophylactic ARR.