Randomized comparative trial of mizoribine versus mycophenolate mofetil in combination with tacrolimus for living donor renal transplantation

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• 作者：Shiro Takahara (1)
  Kota Takahashi (2)
  Takahiro Akiyama (3)
  Kazuharu Uchida (4)
  Kazunari Tanabe (5)
  Noritoshi Amada (6)
  Hiroshi Toma (5)
  
• 关键词：Renal transplantation ; Tacrolimus ; Mycophenolate mofetil ; Mizoribine ; Randomized comparative study
• 刊名：Clinical and Experimental Nephrology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：17
• 期：6
• 页码：899-904
• 全文大小：
• 作者单位：Shiro Takahara (1)
  Kota Takahashi (2)
  Takahiro Akiyama (3)
  Kazuharu Uchida (4)
  Kazunari Tanabe (5)
  Noritoshi Amada (6)
  Hiroshi Toma (5)
  
  1. Department of Advanced Technology for Transplantation, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan
  2. Department of Urology, Niigata University, Niigata, Japan
  3. Sakai Onshinkai Hospital, Sakai, Osaka, Japan
  4. Department of Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan
  5. Department of Urology, Tokyo Women Medical University, Shinjuku-ku, Tokyo, Japan
  6. Department of Surgery, Sendai Shakaihoken Hospital, Sendai, Miyagi, Japan
  
• ISSN：1437-7799

文摘

Background Mizoribine (MZR) was approved in 1984 in Japan for the suppression of rejection in renal transplantation with an approved administration dosage of 1mg/kg/day. The action of MZR resembles that of mycophenolate mofetil (MMF), but MZR dosing is markedly lower than that of MMF. To examine whether higher dosing of MZR could obtain efficacy similar to MMF in renal transplantation, we conducted a comparative study of MZR and MMF using a high daily dose of MZR. Methods A prospective, randomized comparative study of MZR versus MMF using tacrolimus (FK) and steroids as the base was conducted in 35 patients who had undergone living-donor renal transplantation (ABO-incompatible patients were not included) at 8 institutions in Japan between July 2005 and June 2007. Starting doses were 12mg/kg/day for MZR and 2g/day for MMF. Dosages of FK and steroids were set according to the protocol of each institution. Results Patient and graft survival rate at 1year after transplantation was 100% in each group, with no significant difference in rejection rate apparent between groups. Adverse events found in both groups were characteristic, frequently involving infection and digestive organ disorder in the MMF group and elevated uric acid levels in the MZR group. Conclusions Based on these results, MZR and MMF are considered almost equivalent in terms of efficacy and safety.