Telomere length in non-neoplastic gastric mucosa and its relationship to H. pylori infection, degree of gastritis, and NSAID use

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• 作者：Tomomitsu Tahara ; Tomoyuki Shibata ; Tomohiko Kawamura…
• 关键词：Telomere length ; Gastric mucosa ; H. pylori ; DNA methylation ; Ulcer diseases ; NSAIDs
• 刊名：Clinical and Experimental Medicine
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：16
• 期：1
• 页码：65-71
• 全文大小：597 KB
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• 作者单位：Tomomitsu Tahara (1)
  Tomoyuki Shibata (1)
  Tomohiko Kawamura (1)
  Takamitsu Ishizuka (1)
  Masaaki Okubo (1)
  Mitsuo Nagasaka (1)
  Yoshihito Nakagawa (1)
  Tomiyasu Arisawa (2)
  Naoki Ohmiya (1)
  Ichiro Hirata (1)
  
  1. Department of Gastroenterology, Fujita Health University School of Medicine, 1–98 Dengakugakubo Kutsukake-cho, Aichi, Toyoake, 470–1192, Japan
  2. Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  
• 刊物主题：Internal Medicine; Hematology; Oncology;
• 出版者：Springer Milan
• ISSN：1591-9528

文摘

Telomere shortening occurs with human aging in many organs and tissues and is accelerated by rapid cell turnover and oxidative injury. We measured average telomere length using quantitative real-time PCR in non-neoplastic gastric mucosa and assessed its relationship to H. pylori-related gastritis, DNA methylation, ulcer disease, and nonsteroidal anti-inflammatory drug (NSAID) usage. Gastric biopsies were obtained from 151 cancer-free subjects including 49 chronic NSAID users and 102 nonusers. Relative telomere length in genomic DNA was measured by real-time PCR. H. pylori infection status, histological severity of gastritis, and serum pepsinogens (PGs) were also investigated. E-cadherin (CDH1) methylation status was determined by methylation-specific PCR (MSP). Average relative telomere length of H. pylori-infected subjects was significantly shortened when compared to H. pylori-negative subjects (p = 0.002) and was closely associated with all histological parameter of gastritis (all p values <0.01) and CDH1 methylation (p = 0.0002). In H. pylori-negative subjects, NSAID users presented significantly shorter telomere length than nonusers (p = 0.028). Shorter telomere length was observed in duodenal and gastric ulcer patients compared with non-ulcer subjects among NSAID users. Telomere shortening is closely associated with severity of H. pylori-induced gastritis and CDH1 methylation status. Also, telomere shortening is accelerated by NSAID usage especially in H. pylori-negative subjects. Keywords Telomere length Gastric mucosa H. pylori DNA methylation Ulcer diseases NSAIDs