New Antifungal Agents and New Formulations Against Dermatophytes
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- 作者：Aditya K. Gupta ; Kelly A. Foley ; Sarah G. Versteeg
- 关键词：Tinea capitis ; Tinea corporis ; Tinea cruris ; Tinea pedis ; Onychomycosis ; Topical antifungals
- 刊名：Mycopathologia
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：182
- 期：1-2
- 页码：127-141
- 全文大小：631KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Microbiology; Medical Microbiology; Eukaryotic Microbiology; Microbial Ecology; Plant Sciences;
- 出版者：Springer Netherlands
- ISSN：1573-0832
- 卷排序：182
文摘
A variety of oral and topical antifungal agents are available for the treatment of superficial fungal infections caused by dermatophytes. This review builds on the antifungal therapy update published in this journal for the first special issue on Dermatophytosis (Gupta and Cooper 2008;166:353–67). Since 2008, there have not been additions to the oral antifungal armamentarium, with terbinafine, itraconazole, and fluconazole still in widespread use, albeit for generally more severe or recalcitrant infections. Griseofulvin is used in the treatment of tinea capitis. Oral ketoconazole has fallen out of favor in many jurisdictions due to risks of hepatotoxicity. Topical antifungals, applied once or twice daily, are the primary treatment for tinea pedis, tinea corporis/tinea cruris, and mild cases of tinea unguium. Newer topical antifungal agents introduced include the azoles, efinaconazole, luliconazole, and sertaconazole, and the oxaborole, tavaborole. Research is focused on developing formulations of existing topical antifungals that utilize novel delivery systems in order to enhance treatment efficacy and compliance.