The sense behind retroviral anti-sense transcription
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- 作者：Mamneet Manghera ; Alycia Magnusson ; Renée N. Douville
- 关键词：Viral genomes ; Retrovirus ; Human endogenous retrovirus ; K ; Antisense transcription ; Long ; terminal repeat (LTR) ; Transcription factors ; Conserved protein domains
- 刊名：Virology Journal
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：1761KB
- 刊物主题：Virology;
- 出版者：BioMed Central
- ISSN：1743-422X
- 卷排序：14
文摘
Retroviruses are known to rely extensively on the expression of viral proteins from the sense proviral genomic strand. Yet, the production of regulatory retroviral proteins from antisense-encoded viral genes is gaining research attention, due to their clinical significance. This report will discuss what is known about antisense transcription in Retroviridae, and provide new information about antisense transcriptional regulation through a comparison of Human Immunodeficiency Virus (HIV), Human T-cell Lymphotrophic Virus (HTLV-1) and endogenous retrovirus-K (ERVK) long terminal repeats (LTRs). We will attempt to demonstrate that the potential for antisense transcription is more widespread within retroviruses than has been previously appreciated, with this feature being the rule, rather than the exception.