Synthesis, self-assembly, and formation of polymer vesicle hydrogels of thermoresponsive copolymers

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• 作者：Xudong Wang ; Yueqin Duan ; Chenxi Li ; Yan Lu
• 刊名：Journal of Materials Science
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：50
• 期：10
• 页码：3541-3548
• 全文大小：975 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Materials Science
  Characterization and Evaluation Materials
  Polymer Sciences
  Continuum Mechanics and Mechanics of Materials
  Crystallography
  Mechanics
  
• 出版者：Springer Netherlands
• ISSN：1573-4803

文摘

A series of N-isopropylacrylamide and methacrylate derivative random copolymers with various contents of cholic acid groups in the side chain are synthesized by free radical polymerization. These thermoresponsive random copolymers can organize themselves into large vesicles in water upon heating, accompanied by gradual phase transitions from transparent polymer solutions to turbid solutions and then to white hydrogels. The white vesicle hydrogels display non-elastic deformation and shrink. They can re-dissolve directly upon cooling. Further, X-ray diffraction results indicate the existence of crystalline regions on the vesicle membrane. Based on these results, the possible formation mechanism of the fiber-layer structures on the vesicle membrane is also discussed. It is noteworthy that the gel-forming temperatures of the resultant copolymers below 37?°C which indicate the vesicle gels may find applications as injectable implant systems for sustained drug delivery.