Effect of a peptide modeling the nicotinic receptor binding site on the spectral and luminescent properties of dye complexes with cucurbit[8]uril

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• 作者：G. V. Zakharova ; R. R. Konstantinov ; A. V. Odinokov…
• 关键词：peptides ; α ; bungarotoxin ; thiazole orange ; thioflavin T ; cucurbit[8]uril ; complexation ; fluorescence
• 刊名：High Energy Chemistry
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：50
• 期：2
• 页码：121-126
• 全文大小：534 KB
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• 作者单位：G. V. Zakharova (1)
  R. R. Konstantinov (1)
  A. V. Odinokov (1)
  A. K. Chibisov (1)
  M. V. Alfimov (1)
  I. E. Kasheverov (2)
  Yu. N. Utkin (2)
  M. N. Zhmak (2)
  V. I. Tsetlin (2)
  
  1. Photochemistry Center, Russian Academy of Sciences, ul. Novatorov 7a, bldg. 1, Moscow, 119421, Russia
  2. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Physical Chemistry
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3148

文摘

The paper presents the results of analysis of the effect of a high-affinity peptide (HAP) homologous to a fragment of the nicotinic acetylcholine receptor (nAChR) on the absorption and fluorescence spectra of thiazole orange and thioflavin T complexes with cucurbit[8]uril in aqueous solution. In the presence of HAP, a change in the absorption spectra of the dye complexes and a drop in the fluorescence intensity occur; for thiazole orange, the fluorescence intensity is restored to the initial level in the presence of α-bungarotoxin capable of high-affinity binding to nAChR. The proposed method make it possible to detect the presence of α-bungarotoxin.