Persistent Graves’ hyperthyroidism despite rapid negative conversion of thyroid-stimulating hormone-binding inhibitory immunoglobulin assay results: a case report
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- 作者：Nobumasa Ohara ; Masanori Kaneko ; Masaru Kitazawa…
- 关键词：Hyperthyroidism ; Thyroid ; stimulating hormone ; binding inhibitory immunoglobulin ; Graves’ disease ; Thiamazole ; Thyroid scintigraphy ; Human leukocyte antigen
- 刊名：Journal of Medical Case Reports
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：11
- 期：1
- 全文大小：1770KB
- 刊物主题：Medicine/Public Health, general; General Practice / Family Medicine; Public Health; Primary Care Medicine;
- 出版者：BioMed Central
- ISSN：1752-1947
- 卷排序：11
文摘
BackgroundGraves’ disease is an autoimmune thyroid disorder characterized by hyperthyroidism, and patients exhibit thyroid-stimulating hormone receptor antibody. The major methods of measuring circulating thyroid-stimulating hormone receptor antibody include the thyroid-stimulating hormone-binding inhibitory immunoglobulin assays. Although the diagnostic accuracy of these assays has been improved, a minority of patients with Graves’ disease test negative even on second-generation and third-generation thyroid-stimulating hormone-binding inhibitory immunoglobulins. We report a rare case of a thyroid-stimulating hormone-binding inhibitory immunoglobulin-positive patient with Graves’ disease who showed rapid lowering of thyroid-stimulating hormone-binding inhibitory immunoglobulin levels following administration of the anti-thyroid drug thiamazole, but still experienced Graves’ hyperthyroidism.