Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases

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• 作者：Sun Jung Kim
• 关键词：Dendritic cells ; Blimp ; 1 ; Antigen presentation ; SLE
• 刊名：Immunologic Research
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：63
• 期：1-3
• 页码：113-120
• 全文大小：638 KB
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• 作者单位：Sun Jung Kim (1) (2)
  
  1. Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY, 11030, USA
  2. Department of Molecular Medicine, Hofstra-North Shore LIJ School of Medicine, Hempstead, NY, USA
  
• 刊物主题：Allergology; Immunology; Medicine/Public Health, general; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-0755

文摘

Previous studies have identified the immunological functions of transcription factor B lymphocyte-induced maturation protein-1 (Blimp-1) in various adaptive immune cell types such as T and B lymphocytes. More recently, it has been shown that Blimp-1 extends its functional roles to dendritic cells (DCs) and macrophages, two cell types belonging to the innate immune system. The protein acts as a direct and indirect regulator of target genes by recruiting chromatin modification factors and by regulating microRNA expression, respectively. In DCs, Blimp-1 has been identified as one of the components involved in antigen presentation. Genome-wide association studies identified polymorphisms associated with multiple autoimmune diseases such as system lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease in PRDM1, the gene encoding Blimp-1 protein. In this review, we will discuss the immune regulatory functions of Blimp-1 in DCs with a main focus on the tolerogenic mechanisms of Blimp-1 required to protect against the development of autoimmune diseases. Keywords Dendritic cells Blimp-1 Antigen presentation SLE