Macrophages and dendritic cells in the post-testicular environment

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• 作者：Nicolas Da Silva ; Claire R. Barton
• 关键词：Antigen ; presenting cells ; Dendritic cells ; Epididymis ; Macrophages ; Peripheral tolerance ; Sperm maturation ; Spermatozoa
• 刊名：Cell and Tissue Research
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：363
• 期：1
• 页码：97-104
• 全文大小：859 KB
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• 作者单位：Nicolas Da Silva (1)
  Claire R. Barton (1)
  
  1. Division of Nephrology, Center for Systems Biology and Program in Membrane Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, 185 Cambridge Street, CPZN 8.218, Boston, MA 02114-2790, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Proteomics
  Molecular Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0878

文摘

Macrophages (MΦ) and dendritic cells (DCs) are heterogeneous families of functionally and developmentally related immune cells that play crucial roles in tissue homeostasis and the regulation of immune responses. During the past 5 years, immunologists have generated a considerable amount of data that challenge dogmas about the ontogeny and functions of these highly versatile cells. The male excurrent duct system plays a critical role in the establishment of fertility by allowing sperm maturation, transport and storage. In addition, it is challenged by pathogens and must establish a protective and tolerogenic environment for a continuous flow of autoantigenic spermatozoa. The post-testicular environment and, in particular, the epididymis contain an intricate network of DCs and MΦ; however, the immunophysiology of this intriguing and highly specialized mucosal system is poorly understood. This review summarizes the current trends in mouse MΦ and DC biology and speculates about their roles in the steady-state epididymis. Unraveling immune cell functions in the male reproductive tract is an essential prerequisite for the design of innovative strategies aimed at controlling male fertility and treating infertility.