Cytotoxic and DNA topoisomerases I and II inhibitory constituents from the roots ofAralia cordata
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- 作者：Chang-Seob Seo (1)
Gao Li (2) (3)
Chul-Ho Kim (4)
Chong-Soon Lee (5)
Yurngdong Jahng (1)
Hyun-Wook Chang (1)
Jong-Keun Son (1) - 关键词：Aralia cordata ; Araliaceae ; Diterpene ; DNA topoisomerases I and II inhibitor ; Cytotoxicity
- 刊名：Archives of Pharmacal Research
- 出版年：2007
- 出版时间：November 2007
- 年：2007
- 卷：30
- 期：11
- 页码：1404-1409
- 全文大小：650KB
- 参考文献：1. Cai, X. F., Shen, G., Dat, N. T., Kang, O., Lee, Y. M., Lee, J. J., and Kim Y. H., Inhibitory effect of kaurane type diterpenoids from / Acanthopanx koreanum on TNF-α secretion from trypsin-stimulated HMC-1 cells. / Arch. Pharm. Res., 26, 731- 734 (2003). CrossRef
2. Chen, A. Y. and Liu, L. F., DNA topoisomerase: essential enzymes and lethal targets. / Annu. Rev. Pharmacol. Toxicol., 34, 191-18 (1994). CrossRef
3. Dang, N. H., Zhang, X. F., Zheng, M. S., Son, K. H., Chang, H. W., Kim, H. P., Bae, K. H., and Kang, S. S., Inhibitory constituents against cyclooxygenases from / Aralia cordata Thunb. / Arch. Pharm. Res., 28, 28-3 (2005).
4. D’Arpa, P. and Liu, L. F., Topoisomerase-targeting antitumor drugs. / Biochim. Biophys. Acta., 989, 163-77 (1989).
5. Fukuda, M., Nishio, K., Kanzawa, F., Ogasawara, H., Ishida, T., Arioka, H., Bojamowski, k., Oka, M., and Saijo, N., Synergism between cisplatin and topoisomerase I inhibitors, NB-506 and SN-38, in human small cell lung cancer cells. / Cancer Res., 56, 789-93 (1996).
6. Han, B. H., Han, Y. N., Han, L. A., Park, M. H., and Lee E. O., Studies on the anti-inflammatory activity of / Aralia continentalis (I). / Arch. Pharm. Res., 6, 717-3 (1983).
7. Kim, J. S. and Kang, S. S., Saponins from the aerial parts of / Aralia continentalis. / Nat. Prod. Sci., 4, 45-0 (1998).
8. Kim, Y. H., Kim, H. S., Lee, S. W., Masakazu, U., and Lee J. J., Kaurane derivatives from / Acanthopanax koreanum. / Photochemistry, 39, 449-51 (1995). CrossRef
9. Kwon, H. C. and Lee, K. R., Phytochemical constituents of / Artemisia japonica ssp. / littoricola. Arch. Pharm. Res., 24, 194-97 (2001). CrossRef
10. Liu, L. F., DNA topoisomerase poisons as antitumor drugs. / Annu. Rev. Biochem., 58, 351-75 (1989). CrossRef
11. Matsuo, A., Uto, S., Nakayama, M., and Hayashi, S., (-)-thermarol, a new ent-pimarane-class diterpene diol from / Junger- mannia thermarum (Liverwort). / Tetrahedron Lett., 28, 2451- 2454 (1976). CrossRef
12. Mihashi, S., Yanagisawa, I., Tanaka, O., and Shibata, S., Further study on the diterpenes of / Aralia spp. / Tetrahedron Lett., 10, 1683-686 (1969). CrossRef
13. Nagashima, F., Tanaka, H., Takaoka, S., and Asakawa, Y., Sequi- and diterpenoids from the Japanese liverwort / Jungermannia hattoriana. / Phytochemistry, 45, 353-63 (1997). CrossRef
14. Okuyama, E., Nishimura, S., Ohmori, S., Ozaki, Y., Satake, M., and Yamazaki M., Analgesic component of / Notopterygium incisum Ting. / Chem. Pharm. Bull., 41, 926-29 (1993).
15. Okuyama, E., Nishimura, S., and Yamazaki, M., Analgesic principles from / Aralia cordata Thunb. / Chem. Pharm. Bull., 39, 405-07 (1991).
16. Park, S. Y. and Kim, J. W., Cytotoxic polyacetylenes from / Aralia cordata. / Yakhak Hoeji, 39, 681-88 (1995).
17. Pommier, Y., DNA topoisomerase I and II in cancer chemotherapy: update and perspectives. / Cancer Chemother. Pharmacol., 32, 103-08 (1993). CrossRef
18. Potmesil, M., Camptothecins: from bench research to hospital wards. / Cancer Res., 54, 1431-439 (1994).
19. Rubinstein, L. V., Shoemaker, R. H., Paul,K. D., Simon, R. M., Tosini, S., Skehan, P., Scudiero, D. A., Monks, A., and Boyd, M. R., Comparison of in vitro anticancer-drug-screening data generated with a lines. / J. Nat. Cancer Inst., 82, 1113-118 (1990). CrossRef
20. Slichenmyer, W. J., Rowinsky, E. K., Donehower, R. C., and Kaufmann, S. H., The current status of camptothecin analogues as antitumor agents. / J. Natl. Cancer Inst., 85, 271- 291 (1993). CrossRef
21. Tanaka, O., Yasuda, Y., Yamasaki, K., and Mihashi, S., Comparative study on the constituents of some / Aralia species and notice of the original plants of crude drug “Duhuo- / Yakugaku Zasshi, 92, 1058-060 (1972).
22. Wang, J. C., DNA topoisomerases. / Annu. Rev. Biochem., 65, 635-92 (1996). CrossRef
23. Wenkert, E. and Buckwalter, B. L., Carbon-13 nuclear magnetic resonance spectroscopy of naturally occurring substances. X. Pimaradienes. / J. Am. Chem. Soc., 94, 4367-369 (1972). CrossRef
24. Xie, N., Zhong, S. M., Zhao, S. X., Waterman, P. G., He, C. H., and Zheng, Q. T., Diterpenes from Pseuduvaria indochinensis. / J. Chin. Pharm. Univ., 20, 203-07 (1989).
25. Yahara, S., Ishida, M., Yamasaki, K., Tanaka, O., and Mihashi, S., Minor diterpenes of / Aralia cordata Thunb: 17-hydroxy- ent-kaur-15-en-19-oic acid and grandifloric acid. / Chem. Pharm. Bull., 22, 1629-631 (1974). - 作者单位：Chang-Seob Seo (1)
Gao Li (2) (3)
Chul-Ho Kim (4)
Chong-Soon Lee (5)
Yurngdong Jahng (1)
Hyun-Wook Chang (1)
Jong-Keun Son (1)
1. College of Pharmacy, Yeungnam University, 712-749, Gyongsan, Korea
2. Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Yanbian University Ministry of Education, 133000, Yanji, China
3. College of Pharmacy, Yanbian University, 133000, Yanji, China
4. Department of Biological Science, Sungkyunkwan University, 440-746, Suwon, Korea
5. Department of Biochemistry College of Science, Yeungnam University, 712-749, Gyongsan, Korea - ISSN：1976-3786
文摘
Bioactivity-guided fractionation, based on the DNA topoisomerase inhibitory activity, lead to the isolation of five compounds (1-) from the methylene chloride extract of the roots ofAralia cordata Thunb. (Araliaceae). These compounds were identified asent-pimara-8(14),15-dien-19-oic acid (1),ent-pimara-8(14),15-dien-18-oic acid (2), 16α-hydrogen-17-isovaleryloxy-ent-kau-ran-19-oic acid (3), 16α-hydroxy-17-isovaleryloxy-ent-kauran-19-oic acid (4) and dehydrofal-carindiol-8-acetate (5) from their spectral data. Compound3 was isolated for the first time from this plant, and also showed the strongest inhibition of both DNA topoisomerase I and II activities, with 53 and 96% inhibitions, respectively, at a concentration of 20 μM. However, all the compounds exhibited either weak or no cytotoxicities against the human colon carcinoma cell line (HT-29), the human breast carcinoma cell line (MCF-7) and human hepato blastoma cell line (HepG-2).