B-lymphocyte tolerance and effector function in immunity and autoimmunity

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• 作者：Wasif N. Khan (1) <br> Jacqueline A. Wright (1) <br> Eden Kleiman (1) <br> Justin C. Boucher (1) <br> Iris Castro (1) <br> Emily S. Clark (1) <br>
• 关键词：Transitional B cells ; Marginal zone B cells ; Tolerance ; Autoimmunity ; B ; cell antigen receptor ; B ; cell ; activating factor receptor ; Toll ; like receptor ; Apoptosis ; Bruton’s tyrosine kinase ; BH3 ; only protein Bim ; Signaling cross talk
• 刊名：Immunologic Research
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：57
• 期：1-3
• 页码：335-353
• 全文大小：
• 作者单位：Wasif N. Khan (1) <br> Jacqueline A. Wright (1) <br> Eden Kleiman (1) <br> Justin C. Boucher (1) <br> Iris Castro (1) <br> Emily S. Clark (1) <br><br>1. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA <br>
• ISSN：1559-0755

文摘

B-lymphocytes are integral to host defense against microbial pathogens and are associated with many autoimmune diseases. The B-cell receptor implements B-cell self-tolerance based on the antigen specificity, and B-cell-activating factor receptor (BAFF-R) imposes homeostatic control. While shaping the repertoire, the immune tolerance process also culls mature B cells into distinct populations. The activation response of B cells is tailored to the type of pathogen attack and is facilitated by T-cell help via CD40/CD40L interaction and/or innate cell help via toll-like receptors in conjunction with BAFF receptors and ligands. Activated effector B cells not only produce antibodies, but also produce a variety of cytokines to enhance and suppress the immune response. Not surprisingly, B cells play multiple roles in both humoral and cellular immune responses during infection and autoimmune pathogenesis. Here, we discuss how gene expression and signaling networks regulate peripheral B-cell tolerance, B-cell effector functions and emerging therapies targeting B-cell signaling in autoimmune diseases.