Study of the anti-inflammatory effects of low-dose radiation

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• 作者：Martin Large MSc ; Stephanie Hehlgans PhD…
• 关键词：Low ; dose X ; irradiation ; Endothelial cells ; Nuclear factor E2 ; related factor 2 ; Nrf2 ; Antioxidative system ; Anti ; inflammatory action ; Niedrigdosierte Strahlentherapie ; Endothelzellen ; Nukle盲rer Transkriptionsfaktor Nrf2 ; Antioxidatives System ; Antiinflammatorische Aktion
• 刊名：Strahlentherapie und Onkologie
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：191
• 期：9
• 页码：742-749
• 全文大小：721 KB
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• 作者单位：Martin Large MSc (1)
  Stephanie Hehlgans PhD (1)
  Sebastian Reichert PhD (1)
  Udo S. Gaipl PhD (2)
  Claudia Fournier PhD (3)
  Claus R枚del MD (1)
  Christian Weiss MD (1) (4)
  Prof. Dr. rer. nat. Franz R枚del PhD (1)
  
  1. Department of Radiotherapy and Oncology, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany
  2. Department of Radiation Oncology, University Hospital Erlangen, Erlangen, Germany
  3. Department of Biophysics, GSI Helmholtz Center for Heavy Ion Research, Darmstadt, Germany
  4. Institute for Radiooncology and Radiotherapy, Klinikum Darmstadt, Darmstadt, Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Radiotherapy
  Oncology
  
• 出版者：Urban & Vogel
• ISSN：1439-099X

文摘

Background We examined (a) the expression of the antioxidative factor glutathione peroxidase (GPx) and the transcription factor nuclear factor E2-related factor 2 (Nrf2) following low-dose X-irradiation in endothelial cells (ECs) and (b) the impact of reactive oxygen species (ROS) and Nrf2 on functional properties of ECs to gain further knowledge about the anti-inflammatory mode of action of low doses of ionizing radiation.