Inhibition of gap junctional Intercellular communication in WB-F344 rat liver epithelial cells by triphenyltin chloride through MAPK and PI3-kinase pathways
详细信息 查看全文
- 作者：Chung-Hsun Lee (1) (2)
I-Hui Chen (2)
Chia-Rong Lee (2)
Chih-Hsien Chi (1)
Ming-Che Tsai (1)
Jin-Lian Tsai (2)
Hsiu-Fen Lin (2) (3) (4) - 刊名：Journal of Occupational Medicine and Toxicology
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：5
- 期：1
- 全文大小：1374KB
- 参考文献：1. Ueno S, Susa N, Furukawa Y, Komatsu Y, Koyama S, Suzuki T: Butyltin and phenyltin compounds in some marine fishery products on the Japanese market. / Archives of Environmental Health 1999, 54:20. CrossRef
2. Duncan J: The toxicology of molluscicides. The organotins. / Pharmacology & Therapeutics 1980, 10:407鈥?29. CrossRef
3. Kimbrough RG: Toxicity and health effects of selected organotin compounds: A review. / Environmental Health Perspectives 1976, 14:51鈥?6. CrossRef
4. Golub M, Doherty J: Triphenyltin as a potential human endocrine disruptor. / Journal Of Toxicology And Environmental Health Part B, Critical Reviews 2004, 7:281鈥?95. CrossRef
5. Santos MM, Reis-Henriques Armanda M, Natividade Vieira M, Sole M: Triphenyltin and tributyltin, single and in combination, promote imposex in the gastropod Bolinus brandaris. / Ecotoxicology and Environmental Safety 2006, 64:155鈥?62. CrossRef
6. Horiguchi T, Shiraishi H, Shimizu M, Morita M: Effects of triphenyltin chloride and five other organotin compounds on the development of imposex in the rock shell, Thais clavigera. / Environmental Pollution 1997, 95:85鈥?1. CrossRef
7. Shim WJ, Kahng SH, Hong SH, Kim NS, Kim SK, Shim JH: Imposex in the rock shell, Thais clavigera, as evidence of organotin contamination in the marine environment of Korea. / Marine Environmental Research 2000, 49:435鈥?51. CrossRef
8. Boyer IJ: Toxicity of dibutyltin, tributyltin and other organotin compounds to humans and to experimental animals. / Toxicology 1989, 55:253鈥?98. CrossRef
9. Cima F, Ballarin L, Bressa G, Martinucci G, Burighel P: Toxicity of Organotin Compounds on Embryos of a Marine Invertebrate (Styela plicata;Tunicata). / Ecotoxicology and Environmental Safety 1996, 35:174鈥?82. CrossRef
10. Ohhira S, Enomoto M, Matsui H: In vitro metabolism of tributyltin and triphenyltin by human cytochrome P-450 isoforms. / Toxicology 2006, 228:171鈥?77. CrossRef
11. Sarpa M, De-Carvalho RR, Delgado IF, Paumgartten FJR: Development toxicity of triphenyltin hydroxide in mice. / Regulatory Toxicology and Pharmacology 2007, 49:43鈥?2. CrossRef
12. Chicano JJ, Ortiz A, Teruel JA, Aranda FJ: Organotin compounds alter the physical organization of phosphatidylcholine membranes. / Biochimica et Biophysica Acta (BBA) - Biomembranes 2001, 1510:330鈥?41. CrossRef
13. Snoeij NJ, Van Iersel AAJ, Penninks AH, Seinen W: Triorganotin-induced cytotoxicity to rat thymus, bone marrow and red blood cells as determined by several in vitro assays. / Toxicology 1986, 39:71鈥?3. CrossRef
14. Snoeij NJ, Penninks AH, Seinen W: Biological activity of organotin compounds--An overview. / Environmental Research 1987, 44:335鈥?53. CrossRef
15. Whalen MM, Hariharan S, Loganathan BG: Phenyltin Inhibition of the Cytotoxic Function of Human Natural Killer Cells. / Environmental Research 2000, 84:162鈥?69. CrossRef
16. Whalen MM, Wilson S, Gleghorn C, Loganathan BG: Brief exposure to triphenyltin produces irreversible inhibition of the cytotoxic function of human natural killer cells. / Environmental Research 2003, 92:213鈥?20. CrossRef
17. Chipman JK, Mally A, Edwards GO: Disruption of gap junctions in toxicity and carcinogenicity. / Toxicological Sciences: An Official Journal Of The Society Of Toxicology 2003, 71:146鈥?53.
18. Kumar NM, Gilula NB: The Gap Junction Communication Channel. / Cell 1996, 84:381鈥?88. CrossRef
19. Willecke K, Eiberger J, Degen J, Eckardt D, Romualdi A, Goldenagel M, Deutsch U, Suhl G: Structural and functional diversity of connexin genes in the mouse and human genome. / Biological Chemistry 2002, 383:725鈥?37. CrossRef
20. Trosko JE, Ruch RJ: Cell-cell communication in carcinogenesis. / Frontiers In Bioscience: A Journal And Virtual Library 1998, 3:d208鈥?36.
21. Zahler S, Hoffmann A, Gloe T, Pohl U: Gap-junctional coupling between neutrophils and endothelial cells: a novel modulator of transendothelial migration. / Journal Of Leukocyte Biology 2003, 73:118鈥?26. CrossRef
22. Loewenstein WR: Junctional intercellular communication and the control of growth. / Biochimica Et Biophysica Acta 1979, 560:1鈥?5.
23. Huang R, Liu YG, Lin Y, Fan Y, Boynton A, Yang D, Huang RP: Enhanced apoptosis under low serum conditions in human glioblastoma cells by connexin 43 (C贸43). / Molecular Carcinogenesis 2001, 32:128鈥?38. CrossRef
24. Yamasaki H, Naus CCG: Role of connexin genes in growth control. / Commentary 1996, 17:1199鈥?213.
25. Krutovskikh V, Yamasaki H: The role of gap junctional intercellular communication (GJIC) disorders in experimental and human carcinogenesis. / Histology And Histopathology 1997, 12:761鈥?68.
26. Trosko JE, Chang CC, Upham B, Wilson M: Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication. / Toxicology Letters 1998, 102鈥?03:71鈥?8. CrossRef
27. King TJ, Fukushima LH, Hieber AD, Shimabukuro KA, Sakr WA, Bertram JS: Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression. / Carcinogenesis 2000, 21:1097鈥?109. CrossRef
28. Pelin K, Hirvonen A, Linnainmaa K: Expression of cell adhesion molecules and connexins in gap junctional intercellular communication deficient human mesothelioma tumour cell lines and communication competent primary mesothelial cells. / Carcinogenesis 1994, 15:2673鈥?675. CrossRef
29. Lee SW, Tomasetto C, Paul D, Keyomarsi K, Sager R: Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines. / The Journal of Cell Biology 1992, 118:1213鈥?221. CrossRef
30. Garber SA, Fernstrom MJ, Stoner GD, Ruch RJ: Altered gap junctional intercellular communication in neoplastic rat esophageal epithelial cells. / Carcinogenesis 1997, 18:1149鈥?153. CrossRef
31. Tsai H, Werber J, Davia MO, Edelman M, Tanaka KE, Melman A, Christ GJ, Geliebter J: Reduced connexin 43 expression in high grade, human prostatic adenocarcinoma cells. / Biochemical And Biophysical Research Communications 1996, 227:64鈥?9. CrossRef
32. Huang RP, Hossain MZ, Sehgal A, Boynton AL: Reduced connexin43 expression in high-grade human brain glioma cells. / Journal Of Surgical Oncology 1999, 70:21鈥?4. CrossRef
33. Schlemmer SR, Kaufman DG: Endometrial stromal cells regulate gap-junction function in normal human endometrial epithelial cells but not in endometrial carcinoma cells. / Molecular Carcinogenesis 2000, 28:70鈥?5. CrossRef
34. Umhauer S, Ruch RJ, Fanning J: Gap junctional intercellular communication and connexin 43 expression in ovarian carcinoma. / American Journal Of Obstetrics And Gynecology 2000, 182:999鈥?000. CrossRef
35. Murray SA, Davis K, Fishman LM, Bornstein SR: Alpha1 connexin 43 gap junctions are decreased in human adrenocortical tumors. / The Journal Of Clinical Endocrinology And Metabolism 2000, 85:890鈥?95. CrossRef
36. Trosko JE, Upham BL: The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment. / Mutagenesis 2005, 20:81鈥?2. CrossRef
37. Yotti LP, Chang CC, Trosko JE: Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter. / Science (New York, NY) 1979, 206:1089鈥?091. CrossRef
38. Conklin CMJ, Bechberger JF, MacFabe D, Guthrie N, Kurowska EM, Naus CC: Genistein and quercetin increase connexin43 and suppress growth of breast cancer cells. / Carcinogenesis 2007, 28:93鈥?00. CrossRef
39. Nojima H, Ohba Y, Kita Y: Oleamide derivatives are prototypical anti-metastasis drugs that act by inhibiting Connexin 26. / Current Drug Safety 2007, 2:204鈥?11. CrossRef
40. Sai K, Kanno J, Hasegawa R, Trosko JE, Inoue T: Prevention of the down-regulation of gap junctional intercellular communication by green tea in the liver of mice fed pentachlorophenol. / Carcinogenesis 2000, 21:1671鈥?676. CrossRef
41. Sun H, Liu G-t: Chemopreventive effect of dimethyl dicarboxylate biphenyl on malignant transformation of WB-F344 rat liver epithelial cells. / Acta Pharmacologica Sinica 2005, 26:1339鈥?344. CrossRef
42. Trosko JE, Chang CC: Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer. / Mutation Research 2001, 480鈥?81:219鈥?29.
43. Tsao M-S, Smith JD, Nelson KG, Grisham JW: A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells. / Experimental Cell Research 1984, 154:38鈥?2. CrossRef
44. Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. / Journal of Immunological Methods 1983, 65:55鈥?3. CrossRef
45. Shackelford RE, Innes CL, Sieber SO, Heinloth AN, Leadon SA, Paules RS: The Ataxia telangiectasia Gene Product Is Required for Oxidative Stress-induced G1 and G2 Checkpoint Function in Human Fibroblasts. / Journal of Biological Chemistry 2001, 276:21951鈥?1959. CrossRef
46. El-Fouly MH, Trosko JE, Chang C-C: Scrape-loading and dye transfer: A rapid and simple technique to study gap junctional intercellular communication. / Experimental Cell Research 1987, 168:422鈥?30. CrossRef
47. Coons A, Kaplan M: Localization of antigen in tissue cells. II. Improvements in a method for the detection of antigen by means of fluorescent antibody. / J Exptl Med 1950, 91:1鈥?3. CrossRef
48. Wang B-a, Li M, Mu Y-m, Lu Z-h, Li J-y: Effects of tributyltin chloride (TBT) and triphenyltin chloride (TPT) on rat testicular Leydig cells. / Zhonghua Nan Ke Xue 2006, 12:516鈥?19.
49. Ren P, Mehta PP, Ruch RJ: Inhibition of gap junctional intercellular communication by tumor promoters in connexin43 and connexin32-expressing liver cells: cell specificity and role of protein kinase C. / Carcinogenesis 1998, 19:169鈥?75. CrossRef
50. Leithe E, Rivedal E: Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43. / Journal Of Cell Science 2004, 117:1211鈥?220. CrossRef
51. Sirnes S, Leithe E, Rivedal E: The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis. / Biochemical And Biophysical Research Communications 2008, 373:597鈥?01. CrossRef
52. Vikhamar G, Rivedal E, Mollerup S, Sanner T: Role of Cx43 phosphorylation and MAP kinase activation in EGF induced enhancement of cell communication in human kidney epithelial cells. / Cell Adhesion And Communication 1998, 5:451鈥?60. CrossRef
53. Ruch RJ, Trosko JE: Gap-junction communication in chemical carcinogenesis. / Drug Metabolism Reviews 2001, 33:117鈥?24. CrossRef
54. Ruch RandallJ, Trosko JamesE, Madhukar BV: Inhibition of Connexin43 Gap Junctional Intercellular Communication by TPA Requires ERK Activation. / Journal of Cellular Biochemistry 2001, 83:163鈥?69. CrossRef
55. Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR: / A Synthetic Inhibitor of the Mitogen-Activated Protein Kinase Cascade. / Volume 92. Proceedings of the National Academy Sciences of the United States of America; 1995:7686鈥?689.
56. Yang S-R, Cho S-D, Ahn N-S, Jung J-W, Park J-S, Jo E-H, Hwang J-W, Jung J-Y, Kim T-Y, Yoon B-S, / et al.: Role of gap junctional intercellular communication (GJIC) through p38 and ERK1/2 pathway in the differentiation of rat neuronal stem cells. / The Journal Of Veterinary Medical Science/The Japanese Society Of Veterinary Science 2005, 67:291鈥?94.
57. Hakulinen P, Rintala E, Maki-Paakkanen J, Komulainen H: Altered expression of connexin43 in the inhibition of gap junctional intercellular communication by chlorohydroxyfuranones in WB-F344 rat liver epithelial cells. / Toxicology and Applied Pharmacology 2006, 212:146鈥?55. CrossRef
58. Yao J, Morioka T, Oite T: PDGF regulates gap junction communication and connexin43 phosphorylation by PI 3-kinase in mesangial cells. / Kidney International 2000, 57:1915鈥?926. CrossRef
59. Zhang F, Cheng J, Lam G, Jin DK, Vincent L, Hackett NR, Wang S, Young LM, Hempstead B, Crystal RG, Rafii S: Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathways. / Circulation Research 2005, 96:950鈥?57. CrossRef
60. Zhao Y, Rivieccio MA, Lutz S, Scemes E, Brosnan CF: The TLR3 ligand polyI: C downregulates connexin 43 expression and function in astrocytes by a mechanism involving the NF-kappaB and PI3 kinase pathways. / Glia 2006, 54:775鈥?85. CrossRef
61. Barac YD, Zeevi-Levin N, Yaniv G, Reiter I, Milman F, Shilkrut M, Coleman R, Abassi Z, Binah O: The 1,4,5-inositol trisphosphate pathway is a key component in Fas-mediated hypertrophy in neonatal rat ventricular myocytes. / Cardiovascular Research 2005, 68:75鈥?6. CrossRef
62. Gao Q, Katakowski M, Chen X, Li Y, Chopp M: Human marrow stromal cells enhance connexin43 gap junction intercellular communication in cultured astrocytes. / Cell Transplantation 2005, 14:109鈥?17. CrossRef
63. Gekeler V, Boer R, Uberall F, Ise W, Schubert C, Utz I, Hofmann J, Sanders KH, Schachtele C, Klemm K, Grunicke H: Effects of the selective bisindolylmaleimide protein kinase C inhibitor GF 109203X on P-glycoprotein-mediated multidrug resistance. / British Journal Of Cancer 1996, 74:897鈥?05. CrossRef
64. Gekeler V, Boer R, Ise W, Sanders KH, Schachtele C, Beck J: The specific bisindolylmaleimide PKC-inhibitor GF 109203X efficiently modulates MRP-associated multiple drug resistance. / Biochemical And Biophysical Research Communications 1995, 206:119鈥?26. CrossRef
65. Solan JL, Lampe PD: Connexin phosphorylation as a regulatory event linked to gap junction channel assembly. / Biochimica et Biophysica Acta (BBA) - Biomembranes 2005, 1711:154鈥?63. CrossRef
66. Moreno AP, Lau AF: Gap junction channel gating modulated through protein phosphorylation. / Progress in Biophysics and Molecular Biology 2007, 94:107鈥?19. CrossRef
67. Lampe PD, Lau AF: The effects of connexin phosphorylation on gap junctional communication. / The International Journal of Biochemistry & Cell Biology 2004, 36:1171鈥?186. CrossRef
68. Ruch RJ, Bonney WJ, Sigler K, Guan X, Matesic D, Schafer LD, Dupont E, Trosko JE: Loss of gap junctions from DDT-treated rat liver epithelial cells. / Carcinogenesis 1994, 15:301鈥?06. CrossRef
69. Matesic DF, Rupp HL, Bonney WJ, Ruch RJ, Trosko JE: Changes in gap-junction permeability, phosphorylation, and number mediated by phorbol ester and non-phorbol-ester tumor promoters in rat liver epithelial cells. / Molecular Carcinogenesis 1994, 10:226鈥?36. CrossRef
70. Trosko JE, Ruch RJ: Cell-cell communication in carcinogenesis. / Front Biosci 1998, 3:d208鈥?36.
71. Potter VR: A new protocol and its rationale for the study of initiation and promotion of carcinogenesis in rat liver. / Carcinogenesis 1981, 2:1375鈥?379. CrossRef
72. Matsui H, Wada O, Ushijima Y, Akuzawa T: Triphenyltin chloride inhibits superoxide production by human neutrophils stimulated with a surface active agent. / FEBS Letters 1983, 164:251鈥?54. CrossRef
73. McCollister DD, Schober AE: Assessing toxicological properties of organotin Compounds. / Environmental Quality And Safety 1975, 4:80鈥?5.
74. Snoeij NJ, van Iersel AAJ, Penninks AH, Seinen W: Toxicity of triorganotin compounds: Comparative in vivo studies with a series of trialkyltin compounds and triphenyltin chloride in male rats. / Toxicology and Applied Pharmacology 1985, 81:274鈥?86. CrossRef
75. Antizar-Ladislao B: Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. A review. / Environment International 2008, 34:292鈥?08. CrossRef
76. Gould JM: Inhibition by triphenyltin chloride of a tightly-bound membrane component involved in photophosphorylation. / European Journal Of Biochemistry/FEBS 1976, 62:567鈥?75. CrossRef
77. Loewenstein WR, Kanno Y: Intercellular Communication and the Control of Tissue Growth: Lack of Communication between Cancer Cells. / Nature 1966, 209:1248鈥?249. CrossRef
78. Vine AL, Bertram JS: Cancer chemoprevention by connexins. / Cancer and Metastasis Reviews 2002, 21:199鈥?16. CrossRef
79. Udaka N, Miyagi Y, Ito T: Connexin expression in mouse lung tumor. / Cancer Letters 2007, 246:224鈥?29. CrossRef
80. Kamibayashi Y, Oyamada Y, Mori M, Oyamada M: Aberrant expression of gap junction proteins (connexins) is associated with tumor progression during multistage mouse skin carcinogenesis in vivo. / Carcinogenesis 1995, 16:1287鈥?297. CrossRef
81. Asamoto M, Takahashi S, Imaida K, Shirai T, Fukushima S: Increased gap junctional intercellular communication capacity and connexin 43 and 26 expression in rat bladder carcinogenesis. / Carcinogenesis 15:2163鈥?166.
82. Oyamada Y, Oyamada M, Fusco A, Yamasaki H: Aberrant expression, function and localization of connexins in human esophageal carcinoma cell lines with different degrees of tumorigenicity. / Journal of Cancer Research and Clinical Oncology 1995, 120:445鈥?53. CrossRef
83. Hideshima T, Nakamura N, Chauhan D, Anderson KC: Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma. / Oncogene 2001, 20:5991鈥?000. CrossRef
84. Hoarau C, Martin L, Faugaret D, Baron C, Dauba A, Aubert-Jacquin C, Velge-Roussel F, Lebranchu Y: Supernatant from bifidobacterium differentially modulates transduction signaling pathways for biological functions of human dendritic cells. / Plos ONE 2008, 3:e2753-e2753. CrossRef
85. Risbud MV, Fertala J, Vresilovic EJ, Albert TJ, Shapiro IM: Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal. / Spine 2005, 30:882鈥?89. CrossRef
86. Yu C, Rahmani M, Dai Y, Conrad D, Krystal G, Dent P, Grant S: The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. / Cancer Research 2003, 63:1822鈥?833. - 作者单位：Chung-Hsun Lee (1) (2)
I-Hui Chen (2)
Chia-Rong Lee (2)
Chih-Hsien Chi (1)
Ming-Che Tsai (1)
Jin-Lian Tsai (2)
Hsiu-Fen Lin (2) (3) (4)
1. Department of Emergency Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
2. Graduate Institute of Occupational Safety and Health, College of Health Science, Kaohsiung Medical University, 80708, Kaohsiung, Taiwan
3. Department of Ophthalmology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
4. Chang Gung University, College of Medicine, Kaohsiung, Taiwan
文摘
Background Organotin compounds (OTCs) have been widely used as stabilizers in the production of plastic, agricultural pesticides, antifoulant plaints and wood preservation. The toxicity of triphenyltin (TPT) compounds was known for their embryotoxic, neurotoxic, genotoxic and immunotoxic effects in mammals. The carcinogenicity of TPT was not well understood and few studies had discussed the effects of OTCs on gap junctional intercellular communication (GJIC) of cells. Method In the present study, the effects of triphenyltin chloride (TPTC) on GJIC in WB-F344 rat liver epithelial cells were evaluated, using the scrape-loading dye transfer technique. Results TPTC inhibited GJIC after a 30-min exposure in a concentration- and time-dependent manner. Pre-incubation of cells with the protein kinase C (PKC) inhibitor did not modify the response, but the specific MEK 1 inhibitor PD98059 and PI3K inhibitor LY294002 decreased substantially the inhibition of GJIC by TPTC. After WB-F344 cells were exposed to TPTC, phosphorylation of Cx43 increased as seen in Western blot analysis. Conclusions These results show that TPTC inhibits GJIC in WB-F344 rat liver epithelial cells by altering the Cx43 protein expression through both MAPK and PI3-kinase pathways.