Graphene oxide-based drug delivery vehicles: functionalization, characterization, and cytotoxicity evaluation

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• 作者：Sami Makharza (1)
  Giuseppe Cirillo (1) (2)
  Alicja Bachmatiuk (3) (4) (5)
  Imad Ibrahim (1)
  Nicholas Ioannides (6)
  Barbara Trzebicka (5)
  Silke Hampel (1)
  Mark H. Rümmeli (3) (4)
  
• 关键词：Graphene oxide ; Nanocarrier ; Drug therapy ; Health effects ; Nanomedicine
• 刊名：Journal of Nanoparticle Research
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：15
• 期：12
• 全文大小：
• 作者单位：Sami Makharza (1)
  Giuseppe Cirillo (1) (2)
  Alicja Bachmatiuk (3) (4) (5)
  Imad Ibrahim (1)
  Nicholas Ioannides (6)
  Barbara Trzebicka (5)
  Silke Hampel (1)
  Mark H. Rümmeli (3) (4)
  
  1. IFW Dresden, 01171, Dresden, Germany
  2. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Arcavacata di Rende, CS, Italy
  3. IBS Center for Integrated Nanostructure Physics, Institute for Basic Science (IBS), Taejon, 305-701, Republic of Korea
  4. Department of Energy Science, Department of Physics, Sungkyunkwan University, Suwon, 440-746, Republic of Korea
  5. Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, Zabrze, 41-819, Poland
  6. Faculty of Life Sciences and Computing, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK
  
• ISSN：1572-896X

文摘

As a consequence of graphene oxides (GOs) high chemical versatility, there is great interest in functionalized as a nanocarrier for in vitro and in vivo drug delivery. Within this review, the structure and properties of GO that allow covalent and non-covalent functionalization are discussed. In short, toxicity investigations show functionalized GO is biocompatible. Various works demonstrate the potential of GO derivatives as exciting nanocarriers for the loading and delivery of therapeutic drugs.