Traitement des tumeurs d’Ewing: qu’en est-il en 2006?

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• 作者：P. Marec-Bérard (1)
  L. Claude (2)
  
• 关键词：Ewing ; Enfant ; Adolescent ; Adulte ; Traitement ; Facteurs pronostiques ; PNET ; Pluridisciplinarité ; Ewing ; Child ; Teenager ; Adult ; Treatment ; Prognostic factors ; PNET
• 刊名：Oncologie
• 出版年：2007
• 出版时间：February 2007
• 年：2007
• 卷：9
• 期：2
• 页码：152-157
• 全文大小：105KB
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• 作者单位：P. Marec-Bérard (1)
  L. Claude (2)
  
  1. Département d’oncologie pédiatrique, centre Léon-Bérard, 28, rue Laennec, Lyon Cedex 08, F-69008, Lyon, France
  2. Département de radiothérapie, centre Léon-Bérard, 28, rue Laennec, Lyon Cedex 08, F-69008, Lyon, France
  

文摘

A review of the world’s medical literature indicates that all treatment modalities are of interest in Ewing’s sarcoma, the second most common primary bone malignancy in children and adolescence. Chemotherapy increases survival from less than 5% to 65-0% in localized tumors and to 25-0% in primary metastatic tumors. Surgery is a major tool, whereas advances in imaging techniques have improved treatment indication and optimization. Radiotherapy remains useful, either alone or in addition to surgery, and new techniques (conformational RT and IMRT) will reduce short-term toxic effects. However, long-term toxic effects are also of major concern. Pediatric oncologists do not outweigh surgeons or radiation therapists, but they are the ones who conduct the medical orchestra, that also includes pathologists and imaging specialists. This article is a review of the data available in 2006 concerning Ewing’s sarcoma either as biologic aspects as therapeutic aspects.