Morphological brain lesions of pediatric cerebellar tumor survivors correlate with inferior neurocognitive function but do not affect health-related quality of life

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• 作者：Rajiv Kumar Khajuria (1)
  Friederike Blankenburg (1)
  Ines Wuithschick (1)
  Stefan Rueckriegel (1)
  Ulrich-Wilhelm Thomale (2)
  Michael Mansour (3) (4)
  Pablo Hern谩iz Driever (1)
  
  1. Pediatric Neurooncology Program ; Department of Pediatric Oncology and Hematology ; Charit茅-Universit盲tsmedizin Berlin ; Augustenburger Platz 1 ; D-13353 ; Berlin ; Germany
  2. Department of Pediatric Neurosurgery ; Charit茅-Universit盲tsmedizin Berlin ; Augustenburger Platz 1 ; D-13353 ; Berlin ; Germany
  3. Department of Pediatric Radiology ; Charit茅-Universit盲tsmedizin Berlin ; Augustenburger Platz 1 ; D-13353 ; Berlin ; Germany
  4. Department of Diagnostic and Interventional Radiology ; L眉denscheid Hospital ; Paulmannsh枚her Strasse 14 ; D-58515 ; L眉denscheid ; Germany
  
• 关键词：Posterior fossa tumor ; Health ; related quality of life ; Neurocognition ; Brain injury
• 刊名：Child's Nervous System
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：31
• 期：4
• 页码：569-580
• 全文大小：277 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurosurgery
  Neurosciences
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-0350

文摘

Purpose We aimed to determine whether extent of morphological brain injury in pediatric cerebellar tumor survivors correlates with neurocognitive function and health-related quality of life (HrQoL). Methods Seventeen cerebellar pilocytic astrocytoma (cPA) and 17 medulloblastoma (MB) survivors were examined for HrQoL, intelligence using the German version of the WISC-III, attention, working memory, and visual motor coordination. MRI scans were analyzed for extent of posterior fossa brain tissue loss. Results We found significant correlations between amount and extent morphological brain lesions of pediatric cerebellar tumor survivors and several cognitive impairments including intelligence and attention in both patient groups. These were in total more pronounced in MB patients when compared to cPA patients. Still, function loss and brain lesions detected on conventional MRI did not influence HrQoL. Conclusions These findings support the notion that long-term neurocognitive deficits of pediatric posterior fossa tumor survivors significantly correlate with brain tissue damage. The cerebellum plays a role in regulating higher-order functions. On the contrary, the extent brain injury is not detected by HrQoL assessment.