Endometrioseassoziierte maligne Tumoren
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- 作者：Prof. Dr. U. Ulrich (1)
A. Wunschel (1)
V.M. Reichert (1)
S. Darb-Esfahani (2)
D. Denschlag (3)
L.-C. Horn (4)
F. Noack (5)
S.P. Renner (6)
M. Sillem (7)
K.-W. Schweppe (8)
E. Wardelmann (9)
D. Schmidt (10)
1. Klinik f眉r Gyn盲kologie und Geburtshilfe ; Martin-Luther-Krankenhaus ; Caspar-They脽-Str. 27鈥?1 ; 14193 ; Berlin ; Deutschland
2. Institut f眉r Pathologie ; Charit茅 Campus Mitte ; Universit盲tsmedizin Berlin ; Berlin ; Deutschland
3. Frauenklinik ; Hochtaunus-Kliniken ; Bad Homburg ; Deutschland
4. Institut f眉r Pathologie ; Abteilung f眉r Mamma ; Gyn盲ko- und Perinatalpathologie ; Universit盲tsklinikum ; Leipzig ; Deutschland
5. Institut f眉r Pathologie ; Martin-Luther-Krankenhaus ; Berlin ; Deutschland
6. Frauenklinik ; Universit盲tsklinikum ; Erlangen ; Deutschland
7. Praxisklinik am Rosengarten ; Mannheim ; Deutschland
8. Frauenklinik ; Ammerland Klinik ; Westerstede ; Deutschland
9. Gerhard-Domagk-Institut f眉r Pathologie ; Universit盲tsklinikum ; M眉nster ; Deutschland
10. Pathologie Mannheim GmbH ; synlab MVZ ; Mannheim ; Deutschland - 关键词：Maligne Transformation ; Borderline ; Tumoren ; Atypische Endometriose ; Ovarialkarzinom ; Genmutationen ; Malignant transformation ; Borderline tumors ; Atypical endometriosis ; Ovarian cancer ; Gene mutations
- 刊名：Der Gyn?kologe
- 出版年：2015
- 出版时间：March 2015
- 年：2015
- 卷：48
- 期：3
- 页码：221-227
- 全文大小：702 KB
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- 出版者：Springer Berlin Heidelberg
- ISSN：1433-0393
文摘
Malignant tumors can arise from endometriosis with 80鈥? presenting as ovarian cancer and 20鈥? as extragonadal manifestations. This malignant transformation may basically affect every tissue that could potentially harbor endometriosis. A direct cancerous transformation of benign endometriosis through atypias seems to be possible. Histologically, endometriosis-associated malignancies mostly present as endometrioid or clear cell carcinomas, rarely as seromucinous borderline lesions, endometrial stromal sarcomas, adenosarcomas and others. The overall risk of malignancy of endometriosis tissue has been estimated as 1鈥? and 2.5鈥? for ovarian endometriomas with a range between 2鈥? and 17鈥?. PTEN and ARID1A mutations as well as loss of heterozygosity have been reported as molecular genetic findings. Clinically, a more favorable prognosis of these tumors compared to high-grade serous ovarian cancers is being discussed. There are only few systematic studies concerning these tumors. The Endometriosis Research Foundation together with the study groups on ovarian and uterine tumors of the working group for gynecological oncology (AGO) are currently conducting a retrospective study to characterize endometriosis-associated tumors (EAM study). The core component of the study is the expert histopathological second opinion in a reference laboratory.