Stiff person-syndrome IgG affects presynaptic GABAergic release mechanisms

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• 作者：Christian Werner (1) (3)
  Holger Haselmann (1) (2)
  Andreas Weishaupt (3)
  Klaus V. Toyka (3)
  Claudia Sommer (3)
  Christian Geis (1) (2) (3)
  
  1. Hans-Berger Department of Neurology ; Jena University Hospital ; Erlanger Allee ; 07747 ; Jena ; Germany
  3. Department of Neurology ; University Hospital W眉rzburg ; Josef-Schneider Str. 11 ; 97080 ; W眉rzburg ; Germany
  2. Center for Sepsis Control and Care (CSCC) ; Jena University Hospital ; Erlanger Allee 101 ; 07747 ; Jena ; Germany
  
• 关键词：Stiff person ; syndrome ; Glutamate decarboxylase 65 ; GAD2 ; Patch ; clamp ; Synaptic transmission
• 刊名：Journal of Neural Transmission
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：122
• 期：3
• 页码：357-362
• 全文大小：717 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Wien
• ISSN：1435-1463

文摘

The majority of patients with stiff person-syndrome (SPS) are characterized by autoantibodies to glutamate decarboxylase 65 (GAD65). In previous passive-transfer studies, SPS immunoglobulin G (IgG) induced SPS core symptoms. We here provide evidence that SPS-IgG causes a higher frequency of spontaneous vesicle fusions. Sustained GABAergic transmission and presynaptic GABAergic vesicle pool size remained unchanged. Since these findings cannot be attributed to anti-GAD65 autoantibodies alone, we propose that additional autoantibodies with so far undefined antigen specificity might affect presynaptic release mechanisms.