Neural correlates of visual hallucinations in dementia with Lewy bodies

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• 作者：Camille Heitz (1) (2)
  Vincent Noblet (3)
  Benjamin Cretin (1) (2) (3)
  Nathalie Philippi (1) (2) (3)
  Laurent Kremer (1)
  M茅lanie Stackfleth (1) (2)
  Fabrice Hubele (3) (4)
  Jean Paul Armspach (3)
  Izzie Namer (3) (4)
  Fr茅d茅ric Blanc (1) (2) (3)
  
  1. Neuropsychology Unit ; Neurology Department ; University Hospital of Strasbourg ; 1 ; avenue Moli猫re ; 67098 ; Strasbourg ; France
  2. CMRR (Memory Resource and Research Center) ; University Hospital of Strasbourg ; 1 ; avenue Moli猫re ; 67098 ; Strasbourg ; France
  3. University of Strasbourg and CNRS ; ICube Laboratory UMR 7357 ; IMIS team and FMTS (Strasbourg Federation of Translational Medicine) ; 1 ; place de l鈥橦么pital ; 67000 ; Strasbourg ; France
  4. Department of Nuclear Medicine ; University Hospital of Strasbourg ; 1 ; avenue Moli猫re ; 67000 ; Strasbourg ; France
  
• 刊名：Alzheimer's Research & Therapy
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：7
• 期：1
• 全文大小：1,104 KB
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• 刊物主题：Neurosciences; Neurology; Geriatrics/Gerontology;
• 出版者：BioMed Central
• ISSN：1758-9193

文摘

Introduction The aim of this study was to investigate the association between visual hallucinations in dementia with Lewy bodies (DLB) and brain perfusion using single-photon emission computed tomography. Methods We retrospectively included 66 patients with DLB, 36 of whom were having visual hallucinations (DLB-hallu) and 30 of whom were not (DLB-c). We assessed visual hallucination severity on a 3-point scale of increasing severity: illusions, simple visual hallucinations and complex visual hallucinations. We performed voxel-level comparisons between the two groups and assessed correlations between perfusion and visual hallucinations severity. Results We found a significant decrease in perfusion in the left anterior cingulate cortex, the left orbitofrontal cortex and the left cuneus in the DLB-hallu group compared with the DLB-c group. We also found a significant correlation between decreased bilateral anterior cingulate cortex, left orbitofrontal cortex, right parahippocampal gyrus, right inferior temporal cortex and left cuneus perfusion with the severity of hallucinations. Conclusions Visual hallucinations seem to be associated with the impairment of anterior and posterior regions (secondary visual areas, orbitofrontal cortex and anterior cingulate cortex) involved in a top-down and bottom-up mechanism, respectively. Furthermore, involvement of the bilateral anterior cingulate cortex and right parahippocampal gyrus seems to lead to more complex hallucinations.