Prolonged transendothelial migration of human haematopoietic stem and progenitor cells (HSPCs) towards hydrogel-released SDF1

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• 作者：1. Leibniz Institute for Polymer Research Dresden ; Max Bergmann Centre for Biomaterials Dresden ; Hohe Str. 6 ; 01069 Dresden ; Germany2. University Hospital Carl Gustav Carus ; Technical University Dresden ; Fetscher Str. 74 ; 01307 Dresden ; Germany3. Biochemistry and Cell Biology ; Stony Brook University ; Stony Brook ; NY ; USA
• 关键词：HSPC – ; SDF1 – ; Heparin – ; Collagen – ; Migration – ; Gradient
• 刊名：Annals of Hematology
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：90
• 期：8
• 页码：865-871
• 全文大小：298.6 KB
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• 作者单位：http://www.springerlink.com/content/u137326212431383/
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Hematology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0584

文摘

The therapeutic success of haematopoetic stem and progenitor cell (HSPC) transplantation is critically dependent on HSPC engraftment in the bone marrow. Gradients of stromal cell-derived factor 1 (SDF1) direct HSPC homing, both in vitro and in vivo. Potentially, regulating the delivery levels of exogenous SDF1 applied to the bone marrow could augment HSPC engraftment. Thus, the aim of the present study was to revise the ability of biocompatible hydrogels to direct HSPC migration in vitro. The delivery system of choice is based on heparin cross-linked with collagen1. We confirm that hydrogel is capable of trapping and releasing SDF1 and using it to generate a protein gradient in transendothelial migration experiments. The use of SDF1-functionalised hydrogel to produce a chemokine gradient revealed, sustained and increased HSPC migration when compared to diffusible SDF1 controls. In conclusion, regulating SDF1 gradients with heparin-containing hydrogels may offer valuable options to direct site-specific migration of HSPC.