Assessing Lung Inflammation After Nanoparticle Inhalation Using 2-deoxy-2-[18F]fluoro-d-glucose Positron Emission Tomography Imaging
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- 作者：Carlos Pérez-Campa?a (1)
Vanessa Gómez-Vallejo (1)
Maria Puigivila (1)
Abraham Martin (2)
Teresa Calvo-Fernández (3)
Sergio E. Moya (4)
S?ren Thor Larsen (5)
Juan D. Gispert (6)
Jordi Llop (1) - 关键词：Positron emission tomography ; [18F]FDG ; Inflammation ; Lung ; Nanoparticle ; ZnO
- 刊名：Molecular Imaging and Biology
- 出版年：2014
- 出版时间：April 2014
- 年：2014
- 卷：16
- 期：2
- 页码：264-273
- 全文大小：2,784 KB
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Vanessa Gómez-Vallejo (1)
Maria Puigivila (1)
Abraham Martin (2)
Teresa Calvo-Fernández (3)
Sergio E. Moya (4)
S?ren Thor Larsen (5)
Juan D. Gispert (6)
Jordi Llop (1)
1. Radiochemistry Department, Molecular Imaging Unit, CIC biomaGUNE, San Sebastian, Spain
2. Molecular Imaging Unit, CIC biomaGUNE, San Sebastian, Spain
3. Animal Facility, Molecular Imaging Unit, CIC biomaGUNE, San Sebastian, Spain
4. Biosurfaces Unit, CIC biomaGUNE, San Sebastian, Spain
5. National Research Centre for the Working Environment, Copenhagen, Denmark
6. Fundació Pasqual Maragall, Barcelona, Spain - ISSN：1860-2002
文摘
Purpose The aim of the present study was to evaluate the use of 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) as a noninvasive strategy to assess the time course of inflammatory processes after inhalation of ZnO nanoparticles (NPs) in rats. Procedures Healthy, male Sprague–Dawley rats (n--0) were divided in two groups of 15 animals each. Animals from one group (n--5) were submitted to ZnO NPs inhalation in a chamber (10?nm to 4?μm particle size; maximum in number concentration, ?00?nm; concentration--45?mg/m3). Animals from the other group (n--5, sham group) were also exposed following the same procedure, but no NPs were introduced into the chamber. Six animals per group were submitted to [18F]FDG-positron emission tomography (PET) studies at days?1, 7, and 28 after exposition, and the [18F]FDG influx constant (K i ) for the lungs was calculated using Patlak graphical analysis and an image derived blood input function. Nine animals per group were killed at 1, 7 and 28?days after exposure (n-- per group and time point), and the lungs were harvested and submitted to immunohistochemical and histological analysis. Results Significantly higher mean whole-lung K i values were obtained for animals exposed to NPs at days?1 and 7 after exposure (0.0045?±-.0016?min? and 0.0047?±-.0015?min?, respectively) compared to controls (0.0024?±-.0010?min? and 0.0019?±-.0011?min? at 1 and 7?days, respectively). The K i value for exposed animals dropped to 0.0023?±-.0010?min? at day?28. This value was not significantly different from the values obtained at 1, 7, and 28?days for the control group. Immunofluorescence staining on lung tissue slices from animals exposed to ZnO NPs showed an increase in CD11b reactivity at days?1 and 7, followed by a decrease in CD11b positive cells at 28?days. Hematoxylin–eosin staining showed histological alterations in the exposed lungs to ZnO NPs at days?1 and 7 that recovered at 28?days postexposure. Conclusions The [18F]FDG influx rate constant (K i ) could be determined by PET using Patlak analysis and a corrected image derived input function. Higher K i values were obtained for animals exposed to ZnO NPs at days?1 and 7 after exposition. These results were in good concordance with immunohistochemical assays performed on harvested tissue samples.