Absence of long-term effects of reproduction on longevity in the mouse model

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• 作者：Juan J Tarín ; Vanessa Gómez-Piquer…
• 关键词：Fertility ; Gender gap ; Life ; history traits ; Parental investment ; Physiological costs of reproduction ; Trade ; offs ; Survival times
• 刊名：Reproductive Biology and Endocrinology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：12
• 期：1
• 全文大小：440 KB
• 参考文献：1. Speakman, JR (2008) The physiological costs of reproduction in small mammals. Philos Trans R Soc Lond B Biol Sci 363: pp. 375-398 CrossRef
  2. Plumel, MI, Stier, A, Thiersé, D, van Dorsselaer, A, Criscuolo, F, Bertile, F (2014) Litter size manipulation in laboratory mice: an example of how proteomic analysis can uncover new mechanisms underlying the cost of reproduction. Front Zool 11: pp. 41 CrossRef
  3. Williams, GC (1957) Pleiotropy, natural selection, and the evolution of senescence. Evolution 11: pp. 398-411 CrossRef
  4. Atwood, CS, Bowen, RL (2011) The reproductive-cell cycle theory of aging: an update. Exp Gerontol 46: pp. 100-107 CrossRef
  5. Hurt, LS, Ronsmans, C, Thomas, SL (2006) The effect of number of births on women’s mortality: systematic review of the evidence for women who have completed their childbearing. Popul Stud (Camb) 60: pp. 55-71 CrossRef
  6. Le Bourg, E (2007) Does reproduction decrease longevity in human beings?. Ageing Res Rev 6: pp. 141-149 CrossRef
  7. Mitteldorf, J (2010) Female fertility and longevity. Age (Dordr) 32: pp. 79-84 CrossRef
  8. Ricklefs, RE, Cadena, CD (2007) Lifespan is unrelated to investment in reproduction in populations of mammals and birds in captivity. Ecol Lett 10: pp. 867-872 CrossRef
  9. Mace, GM, Pelletier, F (2007) Reproductive investment and lifespan. Ecol Lett 10: pp. 872-874 CrossRef
  10. Larke, A, Crews, DE (2006) Parental investment, late reproduction, and increased reserve capacity are associated with longevity in humans. J Physiol Anthropol 25: pp. 119-131 CrossRef
  11. Aloise King, ED, Garratt, M, Brooks, R (2013) Manipulating reproductive effort leads to changes in female reproductive scheduling but not oxidative stress. Ecol Evol 3: pp. 4161-4171 CrossRef
  12. Brz?k, P, Ksi??ek, A, O?dakowski, ?, Konarzewski, M (2014) High basal metabolic rate does not elevate oxidative stress during reproduction in laboratory mice. J Exp Biol 217: pp. 1504-1509 CrossRef
  13. Yang, DB, Xu, YC, Wang, DH, Speakman, JR (2013) Effects of reproduction on immuno-suppression and oxidative damage, and hence support or otherwise for their roles as mechanisms underpinning life history trade-offs, are tissue and assay dependent. J Exp Biol 216: pp. 4242-4250 CrossRef
  14. Tarín, JJ, Gómez-Piquer, V, Rausell, F, Navarro, S, Hermenegild, C, Cano, A (2005) Delayed motherhood decreases life expectancy of mouse offspring. Biol Reprod 72: pp. 1336-1343 CrossRef
  15. García-Palomares, S, Navarro, S, Pertusa, JF, Hermenegildo, C, García-Pérez, MA, Rausell, F, Cano, A, Tarín, JJ (2009) Delayed fatherhood in mice decreases reproductive fitness and longevity of offspring. Biol Reprod 80: pp. 343-349 CrossRef
  Guide for the Care and Use of Laboratory Animals. National Academies Press, Washington DC
  16. Whittaker, AL, Howarth, GS, Hickman, DL (2012) Effects of space allocation and housing density on measures of wellbeing in laboratory mice: a review. Lab Anim 46: pp. 3-13 CrossRef
  17. Gopalakrishnan, S, Cheung, NK, Yi
• 刊物主题：Reproductive Medicine; Endocrinology;
• 出版者：BioMed Central
• ISSN：1477-7827

文摘

Background Most human demographic data, particularly those on natural fertility populations, find no relationship or even a positive association between fertility and longevity. The present study aims to ascertain whether there is a trade-off between fertility and longevity in the mouse model. Methods The study was focused on the first litter produced by 10- to 14-wk-old hybrid (C57BL/6JIco female X CBA/JIco male) mice. A single female/male per litter was individually housed with a male/female at the age of 25 and 52 wk, respectively, until the end of reproductive life in females or natural death in males under controlled housing conditions. Post-reproductive females and virgin mice were reared until natural death. Cox regression models with forward stepwise variable selection were fitted to examine the effect of several fertility variables on expectation of survival times. Results Virgin females displayed higher life expectancy than virgin males. The relative risk of dying for a virgin male at a particular age was 2.116 [99% confidence interval: 1.317, 3.398] times that of a virgin female. No significant differences on expectation of survival times between virgin and mated females, and between virgin and mated males were found. Furthermore, total number of pups at weaning and total number of litters produced by a dam/stud, time interval between mating and last litter, time interval between litters, and age at last litter were not significant predictors of expectation of survival times in both mated females and mated males. Conclusions Like in most human studies, the present study evidences no relationship between total number of offspring/litters produced by a dam/stud and expectation of survival times. Moreover, the present data are in agreement with the general phenomenon of a bias in life expectancy in favor of females.