High Serum Vaspin Concentrations in Patients with Ulcerative Colitis

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• 作者：Tomohito Morisaki (1)
  Fuminao Takeshima (1)
  Hiroko Fukuda (1)
  Kayoko Matsushima (1)
  Yuko Akazawa (1)
  Naoyuki Yamaguchi (1)
  Ken Ohnita (1)
  Hajime Isomoto (1)
  Hiroaki Takeshita (2)
  Terumitsu Sawai (2)
  Fumihiko Fujita (3)
  Kazuhiko Nakao (1)
  
• 关键词：Adipocytokine ; Vaspin ; Inflammatory bowel disease ; Crohn’s disease ; Ulcerative colitis
• 刊名：Digestive Diseases and Sciences
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：59
• 期：2
• 页码：315-321
• 全文大小：421 KB
• 作者单位：Tomohito Morisaki (1)
  Fuminao Takeshima (1)
  Hiroko Fukuda (1)
  Kayoko Matsushima (1)
  Yuko Akazawa (1)
  Naoyuki Yamaguchi (1)
  Ken Ohnita (1)
  Hajime Isomoto (1)
  Hiroaki Takeshita (2)
  Terumitsu Sawai (2)
  Fumihiko Fujita (3)
  Kazuhiko Nakao (1)
  
  1. Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan
  2. Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
  3. Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
  
• ISSN：1573-2568

文摘

Background Adipocytokines are associated with energy homeostasis and mediate various immune responses and inflammatory processes. Vaspin is a novel adipocytokine that is thought to exhibit anti-inflammatory effects. Aim We aimed to evaluate serum vaspin levels in inflammatory bowel disease (IBD) and determine its possible associations with the course and to clarify its intestinal localization. Methods Serum samples were obtained from patients with Crohn’s disease (CD; n?=?30) and ulcerative colitis (UC; n?=?33) and from healthy volunteers (controls; n?=?26). Enzyme-linked immunosorbent assays were performed for all patients. Vaspin immunohistochemical staining was performed for intestines affected with IBD. Results Serum vaspin concentrations were significantly higher in patients with UC than in patients with CD and controls (422.9?±?361.9 vs. 163.4?±?116.2 vs. 147.5?±?89.4?pg/mL, respectively; P?<?0.01). There was no difference in the serum vaspin concentrations between the patients with CD and controls. There was also no difference in the serum vaspin concentrations between the patients with active IBD and those with inactive IBD. However, the serum vaspin concentrations of most patients with UC increased after remission induction. Vaspin was expressed in the adipocytes of the mesenteric adipose tissues but not in the epithelial or inflammatory cells of large intestines of the patients with IBD. Conclusions Serum vaspin concentrations are elevated in patients with UC and increase further after remission induction, suggesting that vaspin may aid the auxiliary diagnosis of UC and may be useful for assessing disease activity in patients.