Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway
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- 作者：Xiao Zhu (1) (4)
Yi Jiang (2)
Peng-Fei Shan (3)
Jie Shen (4)
Qiu-Hua Liang (1)
Rong-Rong Cui (1)
Yuan Liu (1)
Guan-Ying Liu (1)
Shan-Shan Wu (1)
Qiong Lu (5)
Hui Xie (1)
You-Shuo Liu (6)
Ling-Qing Yuan (1)
Er-Yuan Liao (1) - 关键词：Vaspin ; Osteoblast ; Apoptosis ; Extracellular signal ; regulated kinase
- 刊名：Amino Acids
- 出版年：2013
- 出版时间：March 2013
- 年：2013
- 卷：44
- 期：3
- 页码：961-968
- 全文大小：445KB
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Yi Jiang (2)
Peng-Fei Shan (3)
Jie Shen (4)
Qiu-Hua Liang (1)
Rong-Rong Cui (1)
Yuan Liu (1)
Guan-Ying Liu (1)
Shan-Shan Wu (1)
Qiong Lu (5)
Hui Xie (1)
You-Shuo Liu (6)
Ling-Qing Yuan (1)
Er-Yuan Liao (1)
1. Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People鈥檚 Republic of China
4. Department of Metabolism and Endocrinology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, 510630, People鈥檚 Republic of China
2. Department of Pathology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People鈥檚 Republic of China
3. Department of Endocrinology and Metabolism, The Second Affiliated Hospital, ZheJiang University College of Medicine, Hangzhou, Zhejiang, People鈥檚 Republic of China
5. Institute of Clinical Pharmacy and Pharmacology, Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People鈥檚 Republic of China
6. Geriatric Department, Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People鈥檚 Republic of China - ISSN：1438-2199
文摘
It has been hypothesized that adipocytokines originating from adipose tissue may have an important role in bone metabolism. Vaspin is a novel adipocytokine isolated from visceral white adipose tissue, which has been reported to have anti-apoptotic effects in vascular endothelial cells. However, to the best of our knowledge there is no information regarding the effects of vaspin on osteoblast apoptosis. This study therefore examined the possible effects of vaspin on apoptosis in human osteoblasts (hOBs). Our study established that vaspin inhibits hOBs apoptosis induced by serum deprivation, as determined by ELISA and TUNEL assays. Western blot analysis revealed that vaspin upregulates the expression of Bcl-2 and downregulates that of Bax in a dose-dependent manner. Vaspin stimulated the phosphorylation of ERK, and pretreatment of hOBs with the ERK inhibitor PD98059 blocked the vaspin-induced activation of ERK, however, vaspin did not stimulate the phosphorylation of p38, JNK or Akt. Vaspin protects hOBs from serum deprivation-induced apoptosis, which may be mediated by activating the MAPK/ERK signaling pathway.