Female rats are resistant to developing the depressive phenotype induced by maternal separation stress

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• 作者：J. J. Dimatelis ; I. M. Vermeulen ; K. Bugarith ; D. J. Stein…
• 关键词：Female rats ; Early life stress ; Light exposure ; Behaviour ; MAPK signalling pathway
• 刊名：Metabolic Brain Disease
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：31
• 期：1
• 页码：109-119
• 全文大小：1,333 KB
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• 作者单位：J. J. Dimatelis (1)
  I. M. Vermeulen (1)
  K. Bugarith (1)
  D. J. Stein (2)
  V. A. Russell (1)
  
  1. Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa, 7925
  2. Department of Psychiatry and Mental Health, Groote Schuur Hospital, MRC Unit on Anxiety & Stress Disorders, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, 7925, South Africa
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Neurology
  Biochemistry
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7365

文摘

Many stress-related psychiatric disorders are more common in women than in men. We aimed to determine how female rats respond to maternal separation (MS; removal of the dam from the litter for 3 h/day from postnatal day (P) 2–14)). A subset of MS females were also exposed to chronic constant light for 3 weeks during adolescence (P42–63) to investigate whether the antidepressant effect of light treatment, previously observed in male rats, could be seen in female rats. Ultrasonic vocalizations (22 kHz) were recorded and the forced swim test was conducted immediately after light exposure (P65–67) and 33 days later (P98–99) to determine depressive-like behaviour. Key proteins in the MAPK signal transduction pathway (MKP-1, phospho-ERK, total ERK) and a synaptosomal marker (synaptophysin) were measured in the ventral hippocampus. We found that MS decreased the duration of 22 kHz vocalizations at P65 which was reversed by subsequent light. Light exposure increased time spent in the inner zone of the open field and the number of 22 kHz calls in response to novelty at P98. MS decreased the time females spent immobile and increased time actively swimming in the forced swim test at P67 but not at P99. MKP-1 and synaptophysin levels remained unchanged while MS decreased phospho-ERK levels in the ventral hippocampus. In contrast to clinical findings, the results suggest that female rats may be resistant to MS-induced depression-like behaviour. The behavioural effects of MS and light treatment in female rats may involve the MAPK/ERK signal transduction pathway. Keywords Female rats Early life stress Light exposure Behaviour MAPK signalling pathway