Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor

详细信息    查看全文

• 作者：Mauro De Santi ; Giosuè Annibalini ; Elena Barbieri ; Anna Villarini…
• 关键词：IGF1 pro ; forms ; Breast cancer ; IGF1 receptor
• 刊名：Cellular Oncology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：39
• 期：2
• 页码：149-159
• 全文大小：1,174 KB
• 参考文献：1.S. J. Weroha, P. Haluska, IGF system in cancer. Endocrinol. Metab. Clin. N. Am. 41(335–350) (2012)
  2.M. V. Karamouzis, A. G. Papavassiliou, Targeting insulin-like growth factor in breast cancer therapeutics. Crit. Rev. Oncol. Hematol. 84, 8–17 (2012)CrossRef PubMed
  3.E. Hormones, B. C. C. Group, Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies. Lancet Oncol. 11, 530–542 (2010)
  4.T. O. Nielsen, H. N. Andrews, M. Cheang, J. E. Kucab, F. D. Hsu, J. Ragaz, C. B. Gilks, N. Makretsov, C. D. Bajdik, C. Brookes, L. M. Neckers, V. Evdokimova, D. G. Huntsman, S. E. Dunn, Expression of the insulin-like growth factor I receptor and urokinase plasminogen activator in breast cancer is associated with poor survival: potential for intervention with 17-allylamino geldanamycin. Cancer Res. 64, 286–291 (2004)CrossRef PubMed
  5.E. R. Barton, The ABCs of IGF-I isoforms: impact on muscle hypertrophy and implications for repair. Appl. Physiol. Nutr. Metab. 31, 791–797 (2006)CrossRef PubMed
  6.A. Philippou, M. Maridaki, S. Pneumaticos, M. Koutsilieris, The complexity of the IGF1 gene splicing, posttranslational modification and bioactivity. Mol. Med. 7, 202–214 (2014)
  7.B. K. Brisson, E. R. Barton, New modulators for IGF-I activity within IGF-I processing products. Front. Endocrinol. 27, 42 (2013)
  8.D. R. Powell, P. D. Lee, D. Chang, F. Liu, R. L. Hintz, Antiserum developed for the E peptide region of insulin-like growth factor IA prohormone recognizes a serum protein by both immunoblot and radioimmunoassay. J. Clin. Endocrinol. Metab. 65, 868–875 (1987)CrossRef PubMed
  9.C. A. Conover, B. K. Baker, L. K. Bale, J. T. Clarkson, F. Liu, R. L. Hintz, Human hepatoma cells synthesize and secrete insulin-like growth factor Ia prohormone under growth hormone control. Regul. Pept. 48, 1–8 (1993)CrossRef PubMed
  10.C. A. Conover, B. K. Baker, R. L. Hintz, Cultured human fibroblasts secrete insulin-like growth factor IA prohormone. J. Clin. Endocrinol. Metab. 69, 25–30 (1989)CrossRef PubMed
  11.H. E. Wilson, M. Westwood, A. White, P. E. Clayton, Monoclonal antibodies to the carboxy-terminal Ea sequence of pro-insulin-like growth factor-IA (proIGF-IA) recognize proIGF-IA secreted by IM9 B-lymphocytes. Growth Hormon. IGF Res. 11, 10–17 (2001)CrossRef
  12.E. R. Barton, S. Park, J. K. James, C. A. Makarewich, A. Philippou, D. Eletto, B. Brisson, O. Ostrovsky, Z. Li, Y. Argon, Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production. FASEB J. 26, 3691–3702 (2012)CrossRef PubMed PubMedCentral
  13.J. Durzynska, A. Philippou, B. K. Brisson, M. Nguyen-McCarty, E. R. Barton, The pro-forms of insulin-like growth factor I (IGF-I) are predominant in skeletal muscle and alter IGF-I receptor activation. Endocrinol. 154, 1215–1224 (2013)CrossRef
  14.A. Philippou, E. Papageorgiou, G. Bogdanis, A. Halapas, A. Sourla, M. Maridaki, N. Pissimissis, M. Koutsilieris, Expression of IGF-1 isoforms after exercise-induced muscle damage in humans: characterization of the MGF E peptide actions in vitro. In Vivo 23, 567–575 (2009)PubMed
  15.B. R. McKay, C. E. O’Reilly, S. M. Phillips, M. A. Tarnopolsky, G. Parise, Co-expression of IGF-1 family members with myogenic regulatory factors following acute damaging muscle-lengthening contractions in humans. J. Physiol. 586, 5549–5560 (2008)CrossRef PubMed PubMedCentral
  16.D. S. Milingos, A. Philippou, A. Armakolas, E. Papageorgiou, A. Sourla, A. Protopapas, A. Liapi, A. Antsaklis, M. Mastrominas, M. Koutsilieris, Insulinlike growth factor-1Ec (MGF) expression in eutopic and ectopic endometrium endometrium: characterization of the MGF E-peptide actions in vitro. Mol. Med. 17, 21–28 (2010)PubMed PubMedCentral
  17.A. Armakolas, A. Philippou, Z. Panteleakou, A. Nezos, A. Sourla, C. Petraki, M. Koutsilieris, Preferential expression of IGF-1Ec (MGF) transcript in cancerous tissues of human prostate: evidence for a novel and autonomous growth factor activity of MGF E peptide in human prostate cancer cells. Prostate 70, 1233–1242 (2010)CrossRef PubMed
  18.M. M. Koczorowska, A. Kwasniewska, A. Gozdzicka-Jozefiak, IGF1 mRNA isoform expression in the cervix of HPV-positive women with pre-cancerous and cancer lesions. Exp. Ther. Med. 2, 149–156 (2011)PubMed PubMedCentral
  19.A. Kasprzak, W. Szaflarski, J. Szmeja, M. Andrzejewska, W. Przybyszewska, E. Kaczmarek, M. Koczorowska, T. Kościński, M. Zabel, M. Drews, Differential expression of IGF-1 mRNA isoforms in colorectal carcinoma and normal colon tissue. Int. J. Oncol. 42, 305–316 (2012)PubMed
  20.Y. H. Kuo, T. T. Chen, Novel activities of pro-IGF-I E peptides: regulation of morphological differentiation and anchorage-independent growth in human neuroblastoma cells. Exp. Cell Res. 280, 75–89 (2002)CrossRef PubMed
  21.B. Poudel, D. Bilbao, P. Sarathchandra, R. Germack, N. Rosenthal, M. P. Santini, Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea. Biochem. Biophys. Res. Commun. 416, 293–299 (2011)CrossRef PubMed
  22.T. Norat, L. Dossus, S. Rinaldi, K. Overvad, H. Grønbaek, A. Tjønneland, A. Olsen, F. Clavel-Chapelon, M. C. Boutron-Ruault, H. Boeing, P. H. Lahmann, J. Linseisen, G. Nagel, A. Trichopoulou, D. Trichopoulos, V. Kalapothaki, S. Sieri, D. Palli, S. Panico, R. Tumino, C. Sacerdote, H. B. Bueno-de-Mesquita, P. H. Peeters, C. H. van Gils, A. Agudo, P. Amiano, E. Ardanoz, C. Martinez, R. Quirós, M. J. Tormo, S. Bingham, T. J. Key, N. E. Allen, P. Ferrari, N. Slimani, E. Riboli, R. Kaaks, Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women. Eur. J. Clin. Nutr. 61, 91–98 (2007)CrossRef PubMed
  23.L. Galluzzi, M. De Santi, R. Crinelli, C. De Marco, N. Zaffaroni, A. Duranti, G. Brandi, M. Magnani, Induction of endoplasmic reticulum stress response by the indole-3-carbinol cyclic tetrameric derivative CTet in human breast cancer cell lines. PLoS One 7, e43249 (2012)CrossRef PubMed PubMedCentral
  24.M. De Santi, L. Galluzzi, S. Lucarini, M. F. Paoletti, A. Fraternale, A. Duranti, C. De Marco, M. Fanelli, N. Zaffaroni, G. Brandi, M. Magnani, The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple negative breast cancer cell lines. Breast Cancer Res. 13, R33 (2011)CrossRef PubMed PubMedCentral
  25.S. J. Duguay, W. M. Milewski, B. D. Young, K. Nakayama, D. F. Steiner, Processing of wild-type and mutant proinsulin-like growth factor-IA by subtilisin-related proprotein convertases. J. Biol. Chem. 272, 6663–6670 (1997)CrossRef PubMed
  26.M. S. Hede, E. Salimova, A. Piszczek, E. Perlas, N. Winn, T. Nastasi, N. Rosenthal, E-peptides control bioavailability of IGF-1. PLoS One 7, e51152 (2012)CrossRef PubMed PubMedCentral
  27.E. R. Barton, Viral expression of insulin like growth factor-I isoforms promotes different responses in skeletal muscle. J. Appl. Physiol. 100, 1778–1784 (2006)CrossRef PubMed
  28.M. Vinciguerra, A. Musarò, N. Rosenthal, Regulation of muscle atrophy in aging and disease. Adv. Exp. Med. Biol. 694, 211–233 (2010)CrossRef PubMed
  29.M. P. Santini, L. Tsao, L. Monassier, C. Theodoropoulos, J. Carter, E. Lara-Pezzi, E. Slonimsky, E. Salimova, P. Delafontaine, Y. H. Song, M. Bergmann, C. Freund, K. Suzuki, N. Rosenthal, Enhancing repair of the mammalian heart. Circ. Res. 100, 1732–1740 (2007)CrossRef PubMed PubMedCentral
  30.M. P. Santini, J. Lexow, G. Borsellino, E. Slonimski, E. Zarrinpashneh, T. Poggioli, N. Rosenthal, IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines. Biochem. Biophys. Res. Commun. 410, 201–207 (2011)CrossRef PubMed
  31.Y. Feng, Z. Zhu, X. Xiao, V. Choudhry, J. C. Barrett, D. S. Dimitrov, Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function. Mol. Cancer Ther. 5, 114–120 (2006)CrossRef PubMed
  
• 作者单位：Mauro De Santi (1)
  Giosuè Annibalini (2)
  Elena Barbieri (2)
  Anna Villarini (3)
  Luciana Vallorani (2)
  Serena Contarelli (2)
  Franco Berrino (3)
  Vilberto Stocchi (2)
  Giorgio Brandi (1)
  
  1. Department of Biomolecular Sciences, Hygiene Unit, University of Urbino Carlo Bo, Via S. Chiara, 27 - 61029, Urbino, PU, Italy
  2. Department of Biomolecular Sciences, Exercise and Health Sciences Unit, University of Urbino Carlo Bo, Urbino, PU, Italy
  3. Epidemiology & Prevention Unit, Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  
• 刊物主题：Cancer Research; Biomedicine general; Pathology; Oncology;
• 出版者：Springer Netherlands
• ISSN：2211-3436

文摘

Background IGF1 is a key regulator of tissue growth and development and has been implicated in the initiation and progression of various cancers, including breast cancer. Through IGF1 mRNA splicing different precursor pro-peptides, i.e., the IGF1Ea, IGF1Eb and IGF1Ec pro-forms, are formed whose biological roles in the pathogenesis of breast cancer have not been established yet. The objective of this study was to assess the biological activity of the IGF1 pro-forms in human breast cancer-derived cells.