Initial combination therapy versus step-up therapy in treatment to the target of remission in daily clinical practice in early rheumatoid arthritis patients: results from the DREAM registry
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- 作者：L. M. M. Steunebrink ; G. A. Versteeg ; H. E. Vonkeman…
- 关键词：Treat ; to ; target strategies ; Early rheumatoid arthritis ; Remission ; DAS28
- 刊名：Arthritis Research & Therapy
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：18
- 期：1
- 全文大小：602 KB
- 刊物主题：Rheumatology; Orthopedics;
- 出版者：BioMed Central
- ISSN：1478-6354
文摘
Background Treat to target (T2T) is widely accepted as the standard of care for patients with rheumatoid arthritis (RA) and has been shown to be more effective than traditional routine care. The objective of this study was to compare the effectiveness of two T2T strategies in patients with early RA: a step-up approach starting with methotrexate (MTX) monotherapy (cohort I) versus an initial disease-modifying antirheumatic drug combination approach (cohort II).