Preserve Common Limb in Duodenal–Jejunal Bypass Surgery Benefits Rats with Type 2-Like Diabetes
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- 作者：Shi-Yun Zhang (1)
Xue-Jun Sun (1)
Jian-Bao Zheng (1)
Wei Wang (1)
Dong Liu (1)
Nan-Zheng Chen (1)
Sai He (1)
Xiong-Wei Huo (1)
Wanli Smith (2) - 关键词：Duodenal–jejunal bypass ; Type 2 diabetes ; Goto ; Kakizaki (GK) rat ; Glucagon ; like peptide ; 1 ; Energy intake
- 刊名：Obesity Surgery
- 出版年：2014
- 出版时间：March 2014
- 年：2014
- 卷：24
- 期：3
- 页码：405-411
- 全文大小：277 KB
- 作者单位：Shi-Yun Zhang (1)
Xue-Jun Sun (1)
Jian-Bao Zheng (1)
Wei Wang (1)
Dong Liu (1)
Nan-Zheng Chen (1)
Sai He (1)
Xiong-Wei Huo (1)
Wanli Smith (2)
1. Department of General Surgery, First Affiliated Hospital of Medical College, Xi’an Jiaotong University, 277 West Yanta Road, Xi’an, 710061, People’s Republic of China
2. Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, HSF II, Rm. 563, Baltimore, MD, 21201, USA - ISSN：1708-0428
文摘
Background In order to understand the underlying mechanisms by which weight loss surgeries improve metabolic profiles in type 2 diabetes mellitus (T2DM) patients and to evaluate the relevance of the length of the common limb in modulating various aspects of metabolism, we performed regular duodenal–jejunal bypass (DJB) and long-limb DJB (LL-DJB) surgeries in Goto-Kakizaki (GK) rats and compared their effects on glycemic control. Methods Male GK rats at 12?weeks of age were used for this study. Body weight, food intake, fasting glucose, glucagon-like peptide-1 (GLP-1) level, glucose tolerance, insulin sensitivity, cholesterol and triglycerides levels, and fecal energy content were monitored for 26?weeks after the two types of surgeries. Results We performed systematic analyses on GK rats after DJB or long-limb surgeries. Both procedures prevented body weight gain, reduced blood glucose and lipid levels, increased GLP-1 levels, and led to better insulin sensitivity. In general, LL-DJB displayed better effects than DJB, except that both surgeries caused similar increase in GLP-1 levels. Conclusions Both DJB and LL-DJB surgeries triggered beneficial effects in GK rats. LL-DJB showed better outcomes than DJB, which may be due to reduced food intake and higher fecal energy content. This indicates that the length of the common limb could influence metabolic profiles of surgery recipients.