Association of Lymphotoxin Alpha Polymorphism with Type 1 Diabetes in a Tunisian Population

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• 作者：Mouna Stayoussef (1)
  Ines Zidi (2)
  Jihen Ben Mansour (1)
  Imen Moumni (3)
  Wassim Y. Almawi (4)
  Touhami Mahjoub (1)
  
• 关键词：Type 1 diabetes ; Lymphotoxin alpha ; Polymorphism ; Autoantibodies
• 刊名：Biochemical Genetics
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：52
• 期：1-2
• 页码：79-89
• 全文大小：215 KB
• 作者单位：Mouna Stayoussef (1)
  Ines Zidi (2)
  Jihen Ben Mansour (1)
  Imen Moumni (3)
  Wassim Y. Almawi (4)
  Touhami Mahjoub (1)
  
  1. Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Tunis, Tunisia
  2. Laboratoire Microorganismes et Biomolécules Actives, Sciences Faculty, Tunis El-Manar University, 2092, Tunis, Tunisia
  3. Laboratory of Molecular and Cellular Hematology, Pasteur Institute of Tunis, Tunis El-Manar University, Tunis, Tunisia
  4. College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain
  
• ISSN：1573-4927

文摘

We investigated the association of the lymphotoxin (LT)-α gene polymorphism +249A/G with type 1 diabetes. The distribution of genotypes of the LT-α +249A/G single nucleotide polymorphism (SNP) was assessed in 115 diabetic patients and 123 normoglycemic control subjects, using PCR-restriction fragment length polymorphism analysis. Among unselected patients, the SNP was significantly associated with increased risk of diabetes (χ2?=?8.44, p?=?0.014) and was found to be more pronounced among female (χ2?=?8.37, p?=?0.02) than male (χ2?=?6.11, p?=?0.047) patients. A significant association was detected between LT-α +249A/G and increased risk of diabetes, in particular for young-onset patients (χ2?=?6.92, p?=?0.031). Moreover, we reported significant differences in levels of HbA1c, triglycerides, alanine transaminase, and anti-glutamic acid decarboxylase-65 among alleles. Additional studies with extended patient age groups and different ethnicities are needed to confirm our findings.