Factor VII levels, R353Q and -323P0/10 Factor VII variants, and the risk of acute coronary syndrome among Arab-African Tunisians

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• 作者：Sonia Ben-Hadj-Khalifa (1)
  Basma Lakhal (2)
  Brahim Nsiri (1)
  Touhami Mahjoub (1)
  Wassim Y. Almawi (3)
  
• 关键词：Acute coronary syndrome ; Factor VII ; Polymorphisms ; Tunisia
• 刊名：Molecular Biology Reports
• 出版年：2013
• 出版时间：May 2013
• 年：2013
• 卷：40
• 期：5
• 页码：3793-3798
• 全文大小：192KB
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• 作者单位：Sonia Ben-Hadj-Khalifa (1)
  Basma Lakhal (2)
  Brahim Nsiri (1)
  Touhami Mahjoub (1)
  Wassim Y. Almawi (3)
  
  1. Faculty of Pahrmacy, Research Unit of Biology and Genetics of Hematologic and Autoimmune Diseases, Monastir, Tunisia
  2. Cytogenetics and Biology Department, Farhat Hached University Teaching Hospital, Sousse, Tunisia
  3. Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, PO Box 22979, Manama, Bahrain
  
• ISSN：1573-4978

文摘

The importance of the extrinsic haemostatic system, of which factor VII/VIIa (FVII/FVIIa) is a key constituent, in acute coronary syndrome (ACS) is well recognized. The contribution of FVII gene variants R353Q and -323P0/10, and altered FVII plasma levels to the risk of ACS was investigated in a North African Tunisian Arab cohort consisting of 308 ACS cases and 312 age-, gender- and ethnically-matched control subjects; FVII antigen levels were determined by ELISA. Regression analysis was used in assessing the association of FVII variants and changes in FVII levels to the overall risk of ACS. Significantly higher FVII antigen levels were seen in ACS patients (P?<?0.001), and were associated with ACS and with ACS severity, and this association was confirmed by multivariate regression analysis, after adjusting for a number of confounders (BMI, smoking, systolic blood pressure, hypertension, diabetes, and glucose, cholesterol, and triglycerides levels). While the carriage of 353Q allele, was associated with significant reduction in FVII plasma levels, the distribution of the R353Q genotypes was comparable between cases and control subjects, thereby indicating that altered FVII levels, independent of R353 variant, were associated with increased risk of ACS. In contrast, the -323Ins variant, while not associated with altered FVII plasma levels, was associated with ACS, following adjustment for BMI, smoking, systolic blood pressure, hypertension, diabetes, and glucose, cholesterol, triglycerides and FVII levels. In summary, elevated FVII levels, and the -323P0/10 but not R353Q polymorphism, constitute risk factors for ACS.