Gelatin Microspheres: Correlation between Embolic Effect/Degradability and Cross-linkage/Particle Size

详细信息    查看全文

• 作者：Shinichi Ohta (1)
  Norihisa Nitta (1)
  Shobu Watanabe (1)
  Yuki Tomozawa (1)
  Akinaga Sonoda (1)
  Hideji Otani (1)
  Keiko Tsuchiya (1)
  Ayumi Nitta-Seko (1)
  Atsuko Yamamoto (1)
  Masashi Takahashi (1)
  Kiyoshi Murata (1)
  
• 关键词：Cross ; linkage ; Degradability ; Embolic effect ; Gelatin microspheres ; Particle size
• 刊名：CardioVascular and Interventional Radiology
• 出版年：2013
• 出版时间：August 2013
• 年：2013
• 卷：36
• 期：4
• 页码：1105-1111
• 全文大小：732KB
• 参考文献：1. Yamada R, Sato M, Kawabata M et al (1983) Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology 148:397-01
  2. Camma C, Schepis F, Orlando A et al (2002) Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials. Radiology 224:47-4 CrossRef
  3. Malagari K, Chatzimichael K, Alexopoulou E et al (2008) Transarterial chemoembolization of unresectable hepatocellular carcinoma with drug eluting beads: results of an open-label study of 62 patients. Cardiovasc Intervent Radiol 31:269-80 CrossRef
  4. Varela M, Real MI, Burrel M et al (2007) Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J Hepatol 46:474-81 CrossRef
  5. Poggi G, Quaretti P, Minoia C et al (2008) Transhepatic arterial chemoembolization with oxaliplatin-eluting microspheres (OEM-TACE) for unresectable hepatic tumors. Anticancer Res 28(6B):3835-842
  6. Amesur NB, Zajko AB, Carr BI (2008) Chemo-embolization for unresectable hepatocellular carcinoma with different sizes of embolization particles. Dig Dis Sci 53:1400-404 CrossRef
  7. Tabata Y, Ikada Y (1987) Macrophage activation through phagocytosis of muramyl dipeptide encapsulated in gelatin microspheres. J Pharm Pharmacol 39:698-04 CrossRef
  8. Ohta S, Nitta N, Takahashi M et al (2007) Degradable gelatin microspheres as an embolic agent: an experimental study in a rabbit renal model. Korean J Radiol 8:418-28 CrossRef
  9. Ohta S, Nitta N, Sonoda A et al (2010) Embolization materials made of gelatin: comparison between Gelpart and gelatin microspheres. Cardiovasc Intervent Radiol 33:120-26 CrossRef
  10. Tabata Y, Ikada Y (1989) Synthesis of gelatin microspheres containing interferon. Pharm Res 6:422-27 CrossRef
  
• 作者单位：Shinichi Ohta (1)
  Norihisa Nitta (1)
  Shobu Watanabe (1)
  Yuki Tomozawa (1)
  Akinaga Sonoda (1)
  Hideji Otani (1)
  Keiko Tsuchiya (1)
  Ayumi Nitta-Seko (1)
  Atsuko Yamamoto (1)
  Masashi Takahashi (1)
  Kiyoshi Murata (1)
  
  1. Department of Radiology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu City, Shiga, 520-2192, Japan
  

文摘

Purpose To evaluate the embolic effect and degradability of gelatin microspheres (GMS) using various degrees of cross-linkage and particle sizes in rabbit renal artery embolization. Methods Four types of GMS were used, as follows: 2 types of cross-linkage and 2 types of particle size. Twenty-four rabbits (6 in each group) were used for the renal artery embolization. Renal angiography was performed before and after embolization of right renal artery. Follow-up renal angiography was performed 2 days (n?=?2), 5?days (n?=?2), and 15 days (n?=?2) after embolization in each group, and then kidneys were removed for histopathological evaluation. Vascular areas of the angiography were measured by Image J software, and the reperfusion rate was calculated. In renal specimens, residual GMS were checked and the degree of degradation was classified according to a 4-point scale. Results The mean amounts of large- and small-particle-size GMS injected were 15.0 and 34.3?mg, respectively. Tissue necrosis was confirmed in each group; however, no difference was observed among groups. Renal reperfusion was observed more with small GMS than with large GMS. Renal reperfusion was also observed more with low cross-linked GMS than with high cross-linked GMS. In histopathological specimens, large GMS were confirmed in lobar artery, and small GMS were confirmed in lobular artery. Low cross-linked GMS completely degraded 15 days after embolization. In contrast, high cross-linked GMS were persistent 15 days after embolization. Conclusion Degree of cross-linkage and particle size affected degradability and reperfusion.