IL-15 receptor alpha rs2228059 A>C polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population

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• 作者：Jun Yin (1)
  Liming Wang (2)
  Yijun Shi (1)
  Aizhong Shao (1)
  Weifeng Tang (1)
  Xu Wang (1)
  Wenbo Zhang (3)
  Guowen Ding (1)
  Chao Liu (1)
  Yijang Chen (4)
  Suocheng Chen (1)
  Haiyong Gu (1)
  
• 关键词：IL ; 15RA ; Polymorphisms ; Esophageal cancer ; Molecular epidemiology
• 刊名：Molecular Biology Reports
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：41
• 期：4
• 页码：1951-1957
• 全文大小：198 KB
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• 作者单位：Jun Yin (1)
  Liming Wang (2)
  Yijun Shi (1)
  Aizhong Shao (1)
  Weifeng Tang (1)
  Xu Wang (1)
  Wenbo Zhang (3)
  Guowen Ding (1)
  Chao Liu (1)
  Yijang Chen (4)
  Suocheng Chen (1)
  Haiyong Gu (1)
  
  1. Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 212002, China
  2. Department of Chemotherapy, Medicine Cancer Institute, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 212002, China
  3. Department of General Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 210029, China
  4. Department of Thoracic & Cardiac Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
  
• ISSN：1573-4978

文摘

Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. Esophageal cancer is very aggressive; genetic polymorphisms may explain in part the individual differences in esophageal cancer susceptibility. We conducted a hospital based case–control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs) in the interleukin (IL)-15 and IL-15 receptor alpha (IL-15RA) gene on the development of esophageal cancer. A total of 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for this study. The genotypes were determined using a custom-by-design 48-Plex SNPscanTM kit. The IL-15RA rs2228059 A>C polymorphism was associated with a decreased risk of ESCC in a recessive genetic model; However, there was no significant association between the other five SNPs and ESCC risk. Stratified analyses indicated a significantly decreased risk of ESCC associated with the IL-15RA rs2228059 A>C polymorphism was evident among male, older, non-smoker, and non-drinker patients. These findings indicated that the functional polymorphism, IL-15RA rs2228059 A>C, might contribute to ESCC susceptibility. However, the statistical power of our study was limited because of the moderate sample size and absence of a validation cohort. Large well-designed studies are warranted to confirm our findings.