Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin
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- 作者：Rundi Ma ; Gang Song ; Wenbing You ; Lijian Yu ; Weiming Su ; Mingneng Liao ; Yongping Zhang ; Laizhen Huang ; Xiaoyu Zhang and Tingxi Yu
- 关键词：Bolbostemma paniculatum (Maxim.) Franquet ; Tubeimoside I ; Uptake kinetics ; Anti ; microtubule activity ; Colchicine binding site of tubulin
- 刊名：Cancer Chemotherapy and Pharmacology
- 出版年：2008
- 出版时间：September, 2008
- 年：2008
- 卷：62
- 期：4
- 页码：559-568
- 全文大小：566.7 KB
文摘
Background Tubeimoside I (TBMS1) was isolated from the tubers of Bolbostemma paniculatum (Maxim.) Franquet. TBMS1 shows potent anti-tumor activity. The present study was conducted to investigate the anti-microtubule role of TBMS1 and its binding site of tubulin.