Role of inflammation in the process of clinical Kashin-Beck disease: latest findings and interpretations

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• 作者：Jing Han ; Weizhuo Wang ; Chengjuan Qu ; Ruiyu Liu ; Wenrong Li…
• 关键词：Kashin ; Beck disease ; Inflammation ; Immune response
• 刊名：Inflammation Research
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：64
• 期：11
• 页码：853-860
• 全文大小：732 KB
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• 作者单位：Jing Han (1)
  Weizhuo Wang (2)
  Chengjuan Qu (3)
  Ruiyu Liu (2)
  Wenrong Li (4)
  Zongqiang Gao (2)
  Xiong Guo (1)
  
  1. School of Public Health, Health Science Center, Xi鈥檃n Jiaotong University, No.76 Yanta West Road, Xi鈥檃n, 710061, Shaanxi, People鈥檚 Republic of China
  2. Department of Orthopedics, The Second Affiliated Hospital, Xi鈥檃n Jiaotong University, Xi鈥檃n, 710061, Shaanxi, People鈥檚 Republic of China
  3. Department of Applied Physics, University of Eastern Finland, 70211, Kuopio, Finland
  4. Department of Medical Imaging, The First Affiliated Hospital, Xi鈥檃n Jiaotong University, Xi鈥檃n, 710061, Shaanxi, People鈥檚 Republic of China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Immunology
  Pharmacology and Toxicology
  Allergology
  Dermatology
  Neurology
  Rheumatology
  
• 出版者：Birkh盲user Basel
• ISSN：1420-908X

文摘

Kashin-Beck disease (KBD), a particular type of osteoarthritis (OA), and an endemic disease with articular cartilage damage and chondrocytes apoptosis, can affect many joints, and the most commonly affected joints are the knee, ankle, and hand. KBD has traditionally been classified as a non-inflammatory OA. However, recent studies have shown that inflammation has played an important role in the development of KBD. Nowadays, clinical KBD is not only an endemic disease, but also a combined result of many other non-endemic factors, which contains age, altered biomechanics, joint trauma and secondary OA. The characteristics of the developmental joint failure of advanced KBD, because of the biochemical and mechanical processes, are tightly linked with the interaction of joint damage and its immune response, as well as the subsequent state of chronic inflammation leading to KBD progression. In this review, we focus on the epidemiology, pathology, imaging, cytokines and transduction pathways investigating the association of inflammation with KBD; meanwhile, a wide range of data will be discussed to elicit our current hypotheses considering the role of inflammation and immune activation in KBD development. Keywords Kashin-Beck disease Inflammation Immune response