Quantitative Assessment of HIV-1 Protease Inhibitor Interactions with Drug Efflux Transporters in the Blood¨CBrain Barrier
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- 作者：Corbin J. Bachmeier ; Timothy J. Spitzenberger ; William F. Elmquist and Donald W. Miller
- 关键词：BCECF ; blood– ; brain barrier ; HIV ; 1 protease inhibitors
- 刊名：Pharmaceutical Research
- 出版年：2005
- 出版时间：2005
- 年：2005
- 卷：22
- 期：8
- 页码：1259-1268
- 全文大小：604 KB
文摘
Purpose To quantitatively characterize the drug efflux interactions of various HIV-1 protease inhibitors in an in vitro model of the blood–brain barrier (BBB) and to compare that with HIV-1 protease inhibitor stimulated P-glycoprotein (P-gp)-ATPase activity.