Increased levels of Dickkopf-1 are indicative of Wnt/β-catenin downregulation and lower osteoblast signaling in children and adolescents with type 1 diabetes mellitus, contributing to lower bone mineral density
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- 作者：C. Tsentidis ; D. Gourgiotis ; L. Kossiva ; A. Marmarinos…
- 关键词：Adolescents ; Bone metabolism ; Children ; Dickkopf ; 1 ; Osteoporosis ; Type 1 diabetes
- 刊名：Osteoporosis International
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：28
- 期：3
- 页码：945-953
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Orthopedics; Endocrinology; Rheumatology;
- 出版者：Springer London
- ISSN：1433-2965
- 卷排序：28
文摘
SummaryHigher levels of Dickkopf-1, which is an inhibitor of Wnt/β-catenin bone metabolic pathway, could be indicative of downregulated Wnt system, with possible lower osteoblast activation and higher osteoclast signaling in type 1 diabetes mellitus children and adolescents. Dickkopf-1 could significantly contribute to diabetes osteopathy.