Andrographolide attenuates LPS-stimulated up-regulation of C-C and C-X-C motif chemokines in rodent cortex and primary astrocytes

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• 作者：Siew Ying Wong ; Michelle G.K. Tan ; William A. Banks…
• 关键词：Andrographolide ; Cytokines ; Chemokines ; Astrocyte ; Neuroinflammation
• 刊名：Journal of Neuroinflammation
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：13
• 期：1
• 全文大小：1,075 KB
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• 作者单位：Siew Ying Wong (1)
  Michelle G.K. Tan (1) (2)
  William A. Banks (3) (4)
  W.S. Fred Wong (1) (5)
  Peter T.-H. Wong (1)
  Mitchell K.P. Lai (1)
  
  1. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 16 Medical Drive, Kent Ridge, 117600, Singapore
  2. Department of Clinical Research, Singapore General Hospital, Outram, Singapore
  3. Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
  4. Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Seattle, WA, USA
  5. Immunology Program, Life Science Institute, National University of Singapore, Kent Ridge, Singapore
  
• 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
• 出版者：BioMed Central
• ISSN：1742-2094

文摘

Background Andrographolide is the major bioactive compound isolated from Andrographis paniculata, a native South Asian herb used medicinally for its anti-inflammatory properties. In this study, we aimed to assess andrographolide’s potential utility as an anti-neuroinflammatory therapeutic.