Body mass index and preclinical kidney disease in Indian adults aged 40?years and above without chronic kidney disease
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- 作者：Charumathi Sabanayagam (1) (2) (3)
Tien Yin Wong (1) (2) (3)
Jiemin Liao (3)
Sunil Sethi (4)
Boon Wee Teo (5) - 关键词：CKD ; Cystatin C ; Indians ; Overweight
- 刊名：Clinical and Experimental Nephrology
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：18
- 期：6
- 页码：919-924
- 全文大小：213 KB
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18. Meng L, Yang Y, Qi LT, Wang XJ, Xu GB, Zhang BW. Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function. - 作者单位：Charumathi Sabanayagam (1) (2) (3)
Tien Yin Wong (1) (2) (3)
Jiemin Liao (3)
Sunil Sethi (4)
Boon Wee Teo (5)
1. Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-13, SNEC Bldg, Singapore, 168751, Singapore
2. Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore
3. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
4. Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
5. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore - ISSN：1437-7799
文摘
Background Obesity is associated with diabetes and hypertension, two major risk factors for chronic kidney disease (CKD). Recently, it has been shown that obesity is associated with preclinical kidney disease defined by elevated levels of cystatin C among those without CKD in US adults. However, the association of obesity with cystatin C is not known in industrialized Asian populations. Methods We examined 2,052 Indian adults aged 40-0?years in Singapore who were free of CKD defined as a serum creatinine-based estimated glomerular filtration rate (eGFRcr) 2 and/or the presence of microalbuminuria. Body mass index (BMI) values were categorized into normal (18.5-4.9), overweight (25-9.9) and obese (?0?kg/m2). Elevated serum cystatin C was defined as cystatin C ??mg/L. Results Overweight and obesity were significantly associated with elevated levels of cystatin C after adjusting for potential confounders including diabetes and hypertension and eGFRcr. Compared to those with normal weight, the odds ratio (95?% confidence interval) of elevated cystatin C was 1.49 (1.17-.88) for overweight and 3.20 (2.33-.39) for obese. This association was consistently present when BMI was analyzed as a continuous variable and also in subgroups of men, women and in those without diabetes mellitus or hypertension. Conclusions Higher BMI levels are associated with preclinical kidney disease in Indian adults aged 40?years and above without CKD.