Obesity is associated with a slower response to initial phenprocoumon therapy whereas CYP2C9 genotypes are not
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- 作者：Cordula Meyer zu Schwabedissen ; Vera Mevissen ; Fabian Schmitz ; Seth Woodruff ; Georg Langebartels ; Thomas Rau ; Klaus Zerres ; Rainer Hoffmann and Jan R. Ortlepp
- 关键词：Phenprocoumon ; Genetic polymorphism ; CYP2C9
- 刊名：European Journal of Clinical Pharmacology
- 出版年：2006
- 出版时间：September, 2006
- 年：2006
- 卷：62
- 期：9
- 页码：713-720
- 全文大小：161 KB
文摘
Background Initiation of phenprocoumon therapy is associated with a variable individual response. The CYP2C9 genotype has been shown to influence the response to warfarin therapy, but such an effect on phenprocoumon therapy remains uncertain.